Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1982 Oct;14(4):501–504. doi: 10.1111/j.1365-2125.1982.tb02019.x

The acute effects of ethanol on acetanilide disposition in normal subjects, and in patients with liver disease.

J McKay, M D Rawlings, I Cobden, O F James
PMCID: PMC1427598  PMID: 7138735

Abstract

1 The effects of single doses (25 g and 50 g) oral ethanol on the disposition of acetanilide (50 mg/kg metabolic active mass) has been studied in normal subjects, and in patients with chronic non-alcoholic liver disease. 2 In normal subjects, ethanol produced a dose-dependent increase in acetanilide half-life, and a decrease in acetenilide clearance. There was a significant correlation (rs = 0.71, P less than 0.01) between the 90 min blood ethanol concentration and the reduction in acetanilide clearance. 3 In patients with liver disease, ethanol produced a similar proportional change in acetanilide half-life and clearance, but these were less consistent. Moreover, liver disease itself was associated with an increase in acetenilide half-life, and a reduction in clearance. 4 It is concluded that single oral doses of ethanol, comparable to those consumed during social drinking, may inhibit some forms of microsomal oxidation and thus have important clinical implications.

Full text

PDF
501

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Branch R. A., Herbert C. M., Read A. E. Determinants of serum antipyrine half-lives in patients with liver disease. Gut. 1973 Jul;14(7):569–573. doi: 10.1136/gut.14.7.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buchanan N., Davis M. D., Henderson D. B., Mucklow J. C., Rawlins M. D. Acetanilide pharmacokinetics in kwashiorkor. Br J Clin Pharmacol. 1980 May;9(5):525–526. doi: 10.1111/j.1365-2125.1980.tb05854.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cohen G. M., Mannering G. J. Involvement of a hydrophobic site in the inhibition of the microsomal p-hydroxylation of aniline by alcohols. Mol Pharmacol. 1973 May;9(3):383–397. [PubMed] [Google Scholar]
  4. Cunningham J. L., Bullen M. F., Evans D. A. The pharmacokinetics of acetanilide and of diphenylhydantoin sodium. Eur J Clin Pharmacol. 1974 Oct 4;7(6):461–466. doi: 10.1007/BF00560359. [DOI] [PubMed] [Google Scholar]
  5. Farah F., Taylor W., Rawlins M. D., James O. Hepatic drug acetylation and oxidation: effects of aging in man. Br Med J. 1977 Jul 16;2(6080):155–156. doi: 10.1136/bmj.2.6080.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Iber F. L. Drug metabolism in heavy consumers of ethyl alcohol. Clin Pharmacol Ther. 1977 Nov;22(5 Pt 2):735–742. doi: 10.1002/cpt1977225part2735. [DOI] [PubMed] [Google Scholar]
  7. Jenkins W. J., Peters T. J. Mitochondrial enzyme activities in liver biopsies from patients with alcoholic liver disease. Gut. 1978 May;19(5):341–344. doi: 10.1136/gut.19.5.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LIEBERMAN F. L. The effect of liver disease on the rate of ethanol metabolism in man. Gastroenterology. 1963 Mar;44:261–266. [PubMed] [Google Scholar]
  9. Lieber C. S. Hepatic and metabolic effects of alcohol (1966 to 1973). Gastroenterology. 1973 Nov;65(5):821–846. [PubMed] [Google Scholar]
  10. Misra P. S., Lefévre A., Ishii H., Rubin E., Lieber C. S. Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med. 1971 Sep;51(3):346–351. doi: 10.1016/0002-9343(71)90270-1. [DOI] [PubMed] [Google Scholar]
  11. Powis G. Effect of a single oral dose of methanol, ethanol and propan-2-ol on the hepatic microsomal metabolism of foreign compounds in the rat. Biochem J. 1975 May;148(2):269–277. doi: 10.1042/bj1480269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Powis G., Grant L. The effect of inhibitors of alcohol metabolism upon the changes in the hepatic microsomal metabolism of foreign compounds produced by the acute administration of some alcohols to the rat. Biochem Pharmacol. 1976 Oct 1;25(19):2197–2201. doi: 10.1016/0006-2952(76)90132-5. [DOI] [PubMed] [Google Scholar]
  13. Rubin E., Gang H., Lieber C. S. Interaction of ethanol and pyrazole with hepatic microsomes. Biochem Biophys Res Commun. 1971 Jan 8;42(1):1–8. doi: 10.1016/0006-291x(71)90353-6. [DOI] [PubMed] [Google Scholar]
  14. Schenkman J. B., Remmer H., Estabrook R. W. Spectral studies of drug interaction with hepatic microsomal cytochrome. Mol Pharmacol. 1967 Mar;3(2):113–123. [PubMed] [Google Scholar]
  15. Seitz H. K., Garro A. J., Lieber C. S. Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat. Eur J Clin Invest. 1981 Feb;11(1):33–38. doi: 10.1111/j.1365-2362.1981.tb01762.x. [DOI] [PubMed] [Google Scholar]
  16. Sotaniemi E. A., Ahlqvist J., Pelkonen R. O., Pirttiaho H., Luoma P. V. Histological changes in the liver and indices of drug metabolism in alcoholics. Eur J Clin Pharmacol. 1977 Apr 20;11(4):295–303. doi: 10.1007/BF00607680. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES