Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1978 Aug;33(2):357–359.

Exacerbation of murine malaria by concurrent infection with lactic dehydrogenase-elevating virus.

D C Henderson, C E Tosta, N Wedderburn
PMCID: PMC1537561  PMID: 719954

Abstract

The simultaneous infection of mice with lactic dehydrogenase-elevating virus (LDV) and Plasmodium yoelii resulted in an exacerbated attack of malaria. Peak parasitaemia was higher and the patent infection more prolonged in doubly infected mice. The results indicate that contamination with LDV must be considered when a change in parasite virulence is observed, particularly when the parasite is maintained by blood passage in mice.

Full text

PDF
357

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAILEY J. M., CLOUGH J., STEARMAN M. CLEARANCE OF PLASMA ENZYMES IN NORMAL AND LDH AGENT INFECTED MICE. Proc Soc Exp Biol Med. 1964 Nov;117:350–354. doi: 10.3181/00379727-117-29578. [DOI] [PubMed] [Google Scholar]
  2. Bruce-Chwatt L. J. Les souches de souris résistantes au Plasmodium berghei. Ann Soc Belges Med Trop Parasitol Mycol. 1965;45(3):299–307. [PubMed] [Google Scholar]
  3. Cox F. E., Wedderburn N., Salaman M. H. The effect of Rowson-Parr virus on the severity of malaria in mice. J Gen Microbiol. 1974 Dec;85(2):358–364. doi: 10.1099/00221287-85-2-358. [DOI] [PubMed] [Google Scholar]
  4. Evans R., Salaman M. H. Studies on the mechanism of action of Riley virus. 3. Replication of Riley's plasma enzyme-elevating virus in vitro. J Exp Med. 1965 Nov 1;122(5):993–1002. doi: 10.1084/jem.122.5.993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Howard R. J., Notkins A. L., Mergenhagen S. E. Inhibition of cellular immune reactions in mice infected with lactic dehydrogenase virus. Nature. 1969 Mar 1;221(5183):873–874. doi: 10.1038/221873a0. [DOI] [PubMed] [Google Scholar]
  6. MAHY B. W. ACTION OF RILEY'S PLASMA ENZYME-ELEVATING VIRUS IN MICE. Virology. 1964 Nov;24:481–483. doi: 10.1016/0042-6822(64)90188-6. [DOI] [PubMed] [Google Scholar]
  7. Mahy B. W., Rowson K. E., Parr C. W., Salaman M. H. Studies on the mechanism of action of Riley virus. I. Action of substances affecting the reticuloendothelial system on plasma enzyme levels in mice. J Exp Med. 1965 Nov 1;122(5):967–981. doi: 10.1084/jem.122.5.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Michaelides M. C., Simms E. S. Immune responses in mice infected with lactic dehydrogenase virus. I. Antibody response to DNP-BGG and hyperglobulinaemia in BALB/c mice. Immunology. 1977 Jun;32(6):981–988. [PMC free article] [PubMed] [Google Scholar]
  9. NOTKINS A. L. LACTIC DEHYDROGENASE VIRUS. Bacteriol Rev. 1965 Jun;29:143–160. doi: 10.1128/br.29.2.143-160.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Notkins A. L., Mergenhagen S. E., Rizzo A. A., Scheele C., Waldmann T. A. Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus. J Exp Med. 1966 Feb 1;123(2):347–364. doi: 10.1084/jem.123.2.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. REEVES W. J., Jr, FIMOGNARI G. M. AN IMPROVED PROCEDURE FOR THE PREPARATION OF CRYSTALLINE LACTIC DEHYDROGENASE FROM HOG HEART. J Biol Chem. 1963 Dec;238:3853–3858. [PubMed] [Google Scholar]
  12. Riley V., Lilly F., Huerto E., Bardell D. Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms. Science. 1960 Aug 26;132(3426):545–547. doi: 10.1126/science.132.3426.545. [DOI] [PubMed] [Google Scholar]
  13. Salaman M. H., Wedderburn N., Bruce-Chwatt L. J. The immunodepressive effect of a murine plasmodium and its interaction with murine oncogenic viruses. J Gen Microbiol. 1969 Dec;59(3):383–391. doi: 10.1099/00221287-59-3-383. [DOI] [PubMed] [Google Scholar]
  14. WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]
  15. Walliker D., Sanderson A., Yoeli M., Hargreaves B. J. A genetic investigation of virulence in a rodent malaria parasite. Parasitology. 1976 Apr;72(2):183–194. doi: 10.1017/s0031182000048484. [DOI] [PubMed] [Google Scholar]
  16. Yoeli M., Hargreaves B. J. Brain capillary blockage produced by a virulent strain of rodent malaria. Science. 1974 May 3;184(4136):572–573. doi: 10.1126/science.184.4136.572. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES