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Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1980 Aug;17(4):285–287. doi: 10.1136/jmg.17.4.285

Haemoglobin E trait and probable alpha-thalassaemia in a black American family: a family study.

A F El-Shirbiny, S Parkhurst, R E Bettigole, K D Tourbaf
PMCID: PMC1048571  PMID: 7205904

Abstract

This is a report of haemoglobin E trait in a black American family with no known Asian ancestory. The father appears to be heterozygous for both haemoglobin E and alpha-thalassaemia. The mother is normal both clinically and haematologically. These children carry Hb E trait alone. The youngest son has a normal haemoglobin pattern and appears to have alpha-thalassaemia.

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Selected References

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  1. AKSOY M. Haemoglobins S and E in Turkish people. Nature. 1962 Feb 24;193:786–787. doi: 10.1038/193786a0. [DOI] [PubMed] [Google Scholar]
  2. AKSOY M. The hemoglobin E syndromes. I. Hemoglobin E in Eti-Turks. Blood. 1960 May;15:606–609. [PubMed] [Google Scholar]
  3. BRUMPT L., BRUMPT V., COQUELET M. L., DE TRAVERSE P. M. La détection de l'hémoglobine E; etude des populations cambodgiennes. Rev Hematol. 1958 Jan-Mar;13(1):21–30. [PubMed] [Google Scholar]
  4. BRUMPT L., DE TRAVERSE P. M., COQUELET M. L. Interaction entre hémoglobine E et trait thalassémique au Cambodge. C R Seances Soc Biol Fil. 1956 May 28;150(1):147–151. [PubMed] [Google Scholar]
  5. Bunn H. F., Meriwether W. D., Balcerzak S. P., Rucknagel D. L. Oxygen equilibrium of hemoglobin E. J Clin Invest. 1972 Nov;51(11):2984–2987. doi: 10.1172/JCI107125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CHERNOFF A. I., MINNICH V., NANAKORN S., TUCHINDA S., KASHEMSANT C., BANGKOK, THAILAND, CHERNOFF R. R. Studies on hemoglobin E. I. The clinical, hematologic, and genetic characteristics of the hemoglobin E syndromes. J Lab Clin Med. 1956 Mar;47(3):455–489. [PubMed] [Google Scholar]
  7. Flatz G. Hemoglobin E: distribution and population dynamics. Humangenetik. 1967;3(3):189–234. doi: 10.1007/BF00273124. [DOI] [PubMed] [Google Scholar]
  8. Frischer H., Bowman J. Hemoglobin E, an oxidatively unstable mutation. J Lab Clin Med. 1975 Apr;85(4):531–539. [PubMed] [Google Scholar]
  9. GOUTTAS A., TSEVRENIS H., ROMBOS C., PAPASPYROU A., GARIDI M. [Hemoglobinosis E in Greece]. Sangre (Barc) 1960;31:1–5. [PubMed] [Google Scholar]
  10. HOERMAN K. C., KAMEL K., AWNY A. Y. Haemoglobin E in Egypt. Nature. 1961 Jan 7;189:69–70. doi: 10.1038/189069a0. [DOI] [PubMed] [Google Scholar]
  11. LEHMANN H. Variations in human haemoglobin synthesis and factors governing their inheritance. Br Med Bull. 1959 Jan;15(1):40–46. doi: 10.1093/oxfordjournals.bmb.a069712. [DOI] [PubMed] [Google Scholar]
  12. RAMSAY W. N. The determination of the total iron-binding capacity of serum. Clin Chim Acta. 1957 Jun;2(3):221–226. doi: 10.1016/0009-8981(57)90106-7. [DOI] [PubMed] [Google Scholar]
  13. SINGER K., CHERNOFF A. I., SINGER L. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood. 1951 May;6(5):413–428. [PubMed] [Google Scholar]
  14. Swarup S., Ghosh S. K., Chatterjea J. B. Haemoglobins E and K and thalassemia in an Indian family with evidence of interaction between haemoglobin E and thalassaemia. J Indian Med Assoc. 1966 Jun 1;46(11):587–590. [PubMed] [Google Scholar]

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