Skip to main content
NCBI home page
The Yale Journal of Biology and Medicine logoLink to The Yale Journal of Biology and Medicine
. 1978 May-Jun;51(3):413–418.

Messenger RNA in Compensatory Renal Hypertrophy

AJ Ouellette
PMCID: PMC2595743  PMID: 735161

Abstract

Experiments that deal with the stability of messenger RNA (mRNA) in normal mouse kidney, and, to some extent, the stability of mRNA during renal growth will be described. We have found a population of mRNA in the cytoplasm of mouse kidney that is short-lived. Such a class of rapidly metabolized mRNA could play an adaptive role at the translational or cytoplasmic level in determining gene expression and may be important during the early phases of compensatory hypertrophy.

Full text

PDF
413

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams J. M., Cory S. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA. Nature. 1975 May 1;255(5503):28–33. doi: 10.1038/255028a0. [DOI] [PubMed] [Google Scholar]
  2. Aviv H., Leder P. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408–1412. doi: 10.1073/pnas.69.6.1408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Both G. W., Banerjee A. K., Shatkin A. J. Methylation-dependent translation of viral messenger RNAs in vitro. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1189–1193. doi: 10.1073/pnas.72.3.1189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brawerman G. Eukaryotic messenger RNA. Annu Rev Biochem. 1974;43(0):621–642. doi: 10.1146/annurev.bi.43.070174.003201. [DOI] [PubMed] [Google Scholar]
  5. Comstock J. P., Rosenfeld G. C., O'Malley B. W., Means A. R. Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2377–2380. doi: 10.1073/pnas.69.9.2377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Greenberg J. R. High stability of messenger RNA in growing cultured cells. Nature. 1972 Nov 10;240(5376):102–104. doi: 10.1038/240102a0. [DOI] [PubMed] [Google Scholar]
  7. Greenberg J. R. Isolation of L-cell messenger RNA which lacks poly(adenylate). Biochemistry. 1976 Aug 10;15(16):3516–3522. doi: 10.1021/bi00661a019. [DOI] [PubMed] [Google Scholar]
  8. Greenberg J. R. Messenger RNA metabolism of animal cells. Possible involvement of untranslated sequences and mRNA-associated proteins. J Cell Biol. 1975 Feb;64(2):269–288. doi: 10.1083/jcb.64.2.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hickey E. D., Weber L. A., Baglioni C. Inhibition of initiation of protein synthesis by 7-methylguanosine-5'-monophosphate. Proc Natl Acad Sci U S A. 1976 Jan;73(1):19–23. doi: 10.1073/pnas.73.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lee S. Y., Brawerman G. Pulse-labeled ribonucleic acid complexes released by dissociation of rat liver polysomes. Biochemistry. 1971 Feb 2;10(3):510–516. doi: 10.1021/bi00779a025. [DOI] [PubMed] [Google Scholar]
  11. Melvin W. T., Kumar A., Malt R. A. Conservation of ribosomal RNA during compensatory renal hypertrophy. A major mechanism in RNA accretion. J Cell Biol. 1976 Jun;69(3):548–556. doi: 10.1083/jcb.69.3.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Milcarek C., Price R., Penman S. The metabolism of a poly(A) minus mRNA fraction in HeLa cells. Cell. 1974 Sep;3(1):1–10. doi: 10.1016/0092-8674(74)90030-0. [DOI] [PubMed] [Google Scholar]
  13. Moyer S. A., Abraham G., Adler R., Banerjee A. K. Methylated and blocked 5' termini in vesicular stomatitis virus in vivo mRNAs. Cell. 1975 May;5(1):59–67. doi: 10.1016/0092-8674(75)90092-6. [DOI] [PubMed] [Google Scholar]
  14. Muthukrishnan S., Both G. W., Furuichi Y., Shatkin A. J. 5'-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation. Nature. 1975 May 1;255(5503):33–37. doi: 10.1038/255033a0. [DOI] [PubMed] [Google Scholar]
  15. Muthukrishnan S., Filipowicz W., Sierra J. M., Both G. W., Shatkin A. J., Ochoa S. mRNA methylation and protein synthesis in extracts from embryos of brine shrimp, Artemia salina. J Biol Chem. 1975 Dec 25;250(24):9336–9341. [PubMed] [Google Scholar]
  16. Ouellett A. J., Malt R. A. Accumulation and decay of messenger ribonucleic acid in mouse kidney. Biochemistry. 1976 Jul 27;15(15):3358–3361. doi: 10.1021/bi00660a029. [DOI] [PubMed] [Google Scholar]
  17. Ouellette A. J., Frederick D., Malt R. A. Methylated messenger RNA in mouse kidney. Biochemistry. 1975 Oct 7;14(20):4361–4367. doi: 10.1021/bi00691a003. [DOI] [PubMed] [Google Scholar]
  18. Ouellette A. J., Reed S. L., Malt R. A. Short-lived methylated messenger RNA in mouse kidney. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2609–2613. doi: 10.1073/pnas.73.8.2609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Palmiter R. D., Carey N. H. Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2357–2361. doi: 10.1073/pnas.71.6.2357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Palmiter R. D. Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry. 1974 Aug 13;13(17):3606–3615. doi: 10.1021/bi00714a032. [DOI] [PubMed] [Google Scholar]
  21. Perry R. P., Kelley D. E., Friderici K., Rottman F. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus. Cell. 1975 Apr;4(4):387–394. doi: 10.1016/0092-8674(75)90159-2. [DOI] [PubMed] [Google Scholar]
  22. Perry R. P., Kelley D. E. Messenger RNA turnover in mouse L cells. J Mol Biol. 1973 Oct 5;79(4):681–696. doi: 10.1016/0022-2836(73)90071-5. [DOI] [PubMed] [Google Scholar]
  23. Perry R. P., La Torre J., Kelley D. E., Greenberg J. R. On the lability of poly(A) sequences during extraction of messenger RNA from polyribosomes. Biochim Biophys Acta. 1972 Mar 14;262(2):220–226. doi: 10.1016/0005-2787(72)90236-5. [DOI] [PubMed] [Google Scholar]
  24. Puckett L., Chambers S., Darnell J. E. Short-lived messenger RNA in HeLa cells and its impace on the kinetics of accumulation of cytoplasmic polyadenylate. Proc Natl Acad Sci U S A. 1975 Jan;72(1):389–393. doi: 10.1073/pnas.72.1.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ryffel G. U., McCarthy B. J. Complexity of cytoplasmic RNA in different mouse tissues measured by hybridization of polyadenylated RNA to complementary DNA. Biochemistry. 1975 Apr 8;14(7):1379–1385. doi: 10.1021/bi00678a006. [DOI] [PubMed] [Google Scholar]
  26. Salditt-Georgieff M., Jelinek W., Darnell J. E., Furuichi Y., Morgan M., Shatkin A. Methyl labeling of HeLa cell hnRNA: a comparison with mRNA. Cell. 1976 Feb;7(2):227–237. doi: 10.1016/0092-8674(76)90022-2. [DOI] [PubMed] [Google Scholar]
  27. Shatkin A. J., Banerjee A. K., Both G. W., Furuichi Y., Muthukrishnan S. Dependence of translation on 5'-terminal methylation of mRNA. Fed Proc. 1976 Sep;35(11):2214–2217. [PubMed] [Google Scholar]
  28. Singer R. H., Penman S. Messenger RNA in HeLa cells: kinetics of formation and decay. J Mol Biol. 1973 Aug 5;78(2):321–334. doi: 10.1016/0022-2836(73)90119-8. [DOI] [PubMed] [Google Scholar]
  29. Tweedie J. W., Pitot H. C. Polyadenylate-containing RNA of polyribosomes isolated from rat liver and Morris hepatoma 7800. Cancer Res. 1974 Jan;34(1):109–114. [PubMed] [Google Scholar]
  30. Warner J. R. The assembly of ribosomes in HeLa cells. J Mol Biol. 1966 Aug;19(2):383–398. doi: 10.1016/s0022-2836(66)80012-8. [DOI] [PubMed] [Google Scholar]
  31. Wei C. M., Gershowitz A., Moss B. Methylated nucleotides block 5' terminus of HeLa cell messenger RNA. Cell. 1975 Apr;4(4):379–386. doi: 10.1016/0092-8674(75)90158-0. [DOI] [PubMed] [Google Scholar]
  32. Williams J. G., Penman S. The messenger RNA sequences in growing and resting mouse fibroblasts. Cell. 1975 Oct;6(2):197–206. doi: 10.1016/0092-8674(75)90010-0. [DOI] [PubMed] [Google Scholar]

Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine

RESOURCES