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. 1976 Feb;9(2):343–346. doi: 10.1128/aac.9.2.343

Evaluation of Antibiotic Efficacy Using Electron Microscopy: Morphological Effects of Guanylureido Cephalosporin, BL-P1654, and Carbenicillin on Escherichia coli

L F Ellis 1, D K Herron 1, D A Preston 1, L K Simmons 1, R A Schlegel 1
PMCID: PMC429524  PMID: 773295

Abstract

Early response of Escherichia coli to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [14C]leucine uptake and scanning electron microscopy morphology studies. [14C]leucine uptake was inhibited later by carbenicillin than by BL-P1654 or 112883. Cellular swelling at 30 min, septal region swelling, and lysis were the progressive morphological changes with BL-P1654 and 112883. Carbenicillin-treated cells showed septal region swelling, beaded chains, and lysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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