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. 1994 Oct;102(Suppl 5):127–131. doi: 10.1289/ehp.94102s5127

In vivo evaluation of chemical biopersistence of man-made mineral fibers.

A Morgan 1
PMCID: PMC1567281  PMID: 7882916

Abstract

Techniques developed at the Harwell Laboratory for the determination of the biopersistence of man-made mineral fibers (MMMF) in vivo are described. Results obtained with samples of glass fiber with a range of compositions, and with a sample of rockwool, are summarized. With glass fibers the rate of dissolution of fibers in vivo depends not only on their chemical composition, but also on their length. Certainly, for all fibers exceeding 10 microns in length, the longer the fiber the more rapidly it dissolves. This effect is attributed to differences in the microenvironments to which long and short fibers are exposed. Although this phenomenon appears to operate with all glass fibers, it may not apply to other types of MMMF that dissolve more readily in environments with low pH. Finally, the article examines the validity of the intratracheal method of administration for studying the biopersistence of MMMF in vivo and the use of the rat for this purpose.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellmann B., Muhle H., Pott F., König H., Klöppel H., Spurny K. Persistence of man-made mineral fibres (MMMF) and asbestos in rat lungs. Ann Occup Hyg. 1987;31(4B):693–709. doi: 10.1093/annhyg/31.4b.693. [DOI] [PubMed] [Google Scholar]
  2. Hesterberg T. W., Barrett J. C. Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Carcinogenesis. 1985 Mar;6(3):473–475. doi: 10.1093/carcin/6.3.473. [DOI] [PubMed] [Google Scholar]
  3. Holmes A., Morgan A., Davison W. Formation of pseudo-asbestos bodies on sized glass fibres in the hamster lung. Ann Occup Hyg. 1983;27(3):301–313. doi: 10.1093/annhyg/27.3.301. [DOI] [PubMed] [Google Scholar]
  4. Le Guen J. M., Galvin S. Clearing and mounting techniques for the evaluation of asbestos fibres by the membrane filter method. Ann Occup Hyg. 1981;24(3):273–280. doi: 10.1093/annhyg/24.3.273. [DOI] [PubMed] [Google Scholar]
  5. McDonald J. C., Case B. W., Enterline P. E., Henderson V., McDonald A. D., Plourde M., Sébastien P. Lung dust analysis in the assessment of past exposure of man-made mineral fibre workers. Ann Occup Hyg. 1990 Oct;34(5):427–441. doi: 10.1093/annhyg/34.5.427. [DOI] [PubMed] [Google Scholar]
  6. Monchaux G., Bignon J., Jaurand M. C., Lafuma J., Sebastien P., Masse R., Hirsch A., Goni J. Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. Carcinogenesis. 1981;2(3):229–236. doi: 10.1093/carcin/2.3.229. [DOI] [PubMed] [Google Scholar]
  7. Morgan A., Collier C. G., Morris K. J., Launder K. A. A radioactive tracer technique to determine in vivo the number of fibers in the lungs of rats following their administration by intratracheal instillation. Environ Res. 1993 Nov;63(2):182–190. doi: 10.1006/enrs.1993.1139. [DOI] [PubMed] [Google Scholar]
  8. Morgan A., Davies P., Wagner J. C., Berry G., Holmes A. The biological effects of magnesium-leached chrysotile asbestos. Br J Exp Pathol. 1977 Oct;58(5):465–473. [PMC free article] [PubMed] [Google Scholar]
  9. Morgan A. Effect of length on the clearance of fibres from the lung and on body formation. IARC Sci Publ. 1980;(30):329–335. [PubMed] [Google Scholar]
  10. Morgan A., Holmes A., Davison W. Clearance of sized glass fibres from the rat lung and their solubility in vivo. Ann Occup Hyg. 1982;25(3):317–331. doi: 10.1093/annhyg/25.3.317. [DOI] [PubMed] [Google Scholar]
  11. Morgan A., Holmes A. Solubility of asbestos and man-made mineral fibers in vitro and in vivo: its significance in lung disease. Environ Res. 1986 Apr;39(2):475–484. doi: 10.1016/s0013-9351(86)80071-8. [DOI] [PubMed] [Google Scholar]
  12. Morgan A., Holmes A. Solubility of rockwool fibres in vivo and the formation of pseudo-asbestos bodies. Ann Occup Hyg. 1984;28(3):307–314. doi: 10.1093/annhyg/28.3.307. [DOI] [PubMed] [Google Scholar]
  13. Pritchard J. N., Holmes A., Evans J. C., Evans N., Evans R. J., Morgan A. The distribution of dust in the rat lung following administration by inhalation and by single intratracheal instillation. Environ Res. 1985 Apr;36(2):268–297. doi: 10.1016/0013-9351(85)90025-8. [DOI] [PubMed] [Google Scholar]

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