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. 1994 Jul;97(1):45–47. doi: 10.1111/j.1365-2249.1994.tb06577.x

Polymorphism of tumour necrosis factor-alpha (TNF-alpha) at position -308 in relation to ankylosing spondylitis.

G M Verjans 1, B M Brinkman 1, C E Van Doornik 1, A Kijlstra 1, C L Verweij 1
PMCID: PMC1534773  PMID: 8033419

Abstract

In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-alpha alleles was determined in 66 AS patients and 37 healthy controls. The TNF-alpha allele frequency was not significantly different between AS patients and controls.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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