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. 1994 Jan 15;297(Pt 2):379–384. doi: 10.1042/bj2970379

Platelet-derived growth factor (PDGF)-AB-mediated phosphorylation of PDGF beta receptors.

S R Coats 1, H D Love 1, W J Pledger 1
PMCID: PMC1137840  PMID: 8297345

Abstract

Platelet-derived growth factor (PDGF) stimulates the proliferation of Balb/c-3T3 fibroblasts through binding and subsequent activation of PDGF receptors. Activation of the PDGF receptors has been proposed to involve receptor dimerization. PDGF-AB has been shown to bind PDGF alpha and beta receptor subunits to form PDGF alpha beta and alpha alpha receptor dimers. In this paper we demonstrate that, following the down-regulation of PDGF alpha receptors, the binding of PDGF-AB to beta receptors occurred at 37 degrees C but not at 4 degrees C. PDGF-AB stimulated the phosphorylation of PDGF beta receptor monomers in cells depleted of PDGF alpha receptors by prior exposure to PDGF-AA.

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Selected References

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