Abstract
Cotinine levels in the semen, urine, and blood of 88 male smokers and nonsmokers, aged 18 to 35, were analyzed via radioimmunoassay. Detectable cotinine levels were found in all three body fluids, and cotinine levels in all three fluids were highly correlated. Cotinine levels in semen and blood were of similar magnitude; cotinine levels in urine were an order of magnitude or more higher. In all three fluids, cotinine levels increased with an increase in cigarette smoke exposure.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Jarvis M. J., Russell M. A., Benowitz N. L., Feyerabend C. Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure. Am J Public Health. 1988 Jun;78(6):696–698. doi: 10.2105/ajph.78.6.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jarvis M. J., Tunstall-Pedoe H., Feyerabend C., Vesey C., Saloojee Y. Comparison of tests used to distinguish smokers from nonsmokers. Am J Public Health. 1987 Nov;77(11):1435–1438. doi: 10.2105/ajph.77.11.1435. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Langone J. J., Gjika H. B., Van Vunakis H. Nicotine and its metabolites. Radioimmunoassays for nicotine and cotinine. Biochemistry. 1973 Nov 20;12(24):5025–5030. doi: 10.1021/bi00748a032. [DOI] [PubMed] [Google Scholar]
- Thompson S. G., Barlow R. D., Wald N. J., Van Vunakis H. How should urinary cotinine concentrations be adjusted for urinary creatinine concentration? Clin Chim Acta. 1990 Mar 15;187(3):289–295. doi: 10.1016/0009-8981(90)90114-8. [DOI] [PubMed] [Google Scholar]
- Wall M. A., Johnson J., Jacob P., Benowitz N. L. Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. Am J Public Health. 1988 Jun;78(6):699–701. doi: 10.2105/ajph.78.6.699. [DOI] [PMC free article] [PubMed] [Google Scholar]