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. 1996 Mar;223(3):297–302. doi: 10.1097/00000658-199603000-00011

Hepatocellular carcinoma and cirrhosis. Results of surgical treatment in a European series.

J Fuster 1, J C García-Valdecasas 1, L Grande 1, J Tabet 1, J Bruix 1, T Anglada 1, P Taurá 1, A M Lacy 1, X González 1, R Vilana 1, C Bru 1, M Solé 1, J Visa 1
PMCID: PMC1235119  PMID: 8604911

Abstract

OBJECTIVE: The authors analyze the outcomes of patients with hepatocellular carcinoma (HCC) and cirrhosis who underwent liver resections. BACKGROUND: Liver resection is the best option for HCC arising from hepatic cirrhosis. The experience of Western centers with these patients is shorter than the Asian series. METHODS: Forty-eight consecutive patients with cirrhosis and HCC who underwent liver resections were studied after a similar diagnostic and therapeutic process. Survival and cumulative recurrence were calculated according to pathologic findings. RESULTS: Factors influencing survival at 3 years were as follows: type of resection, absence of vascular invasion, size of the tumor, absence of satellite nodules, and the number of nodules. Factors influencing the rate of recurrence at 3 years were the presence of vascular invasion and the presence of satellite nodules. Patients with favorable prognostic factors have a good survival rate with an acceptable recurrence rate. CONCLUSIONS: Identification of prognostic factors may help in the selection of the appropriate treatment for these patients with HCC and cirrhosis.

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Selected References

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  1. Belghiti J., Panis Y., Farges O., Benhamou J. P., Fekete F. Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis. Ann Surg. 1991 Aug;214(2):114–117. doi: 10.1097/00000658-199108000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Belghiti J. Resection of hepatocellular carcinoma complicating cirrhosis. Br J Surg. 1991 Mar;78(3):257–258. doi: 10.1002/bjs.1800780302. [DOI] [PubMed] [Google Scholar]
  3. Bismuth H., Houssin D., Ornowski J., Meriggi F. Liver resections in cirrhotic patients: a Western experience. World J Surg. 1986 Apr;10(2):311–317. doi: 10.1007/BF01658152. [DOI] [PubMed] [Google Scholar]
  4. Boix L., Bruix J., Campo E., Sole M., Castells A., Fuster J., Rivera F., Cardesa A., Rodes J. nm23-H1 expression and disease recurrence after surgical resection of small hepatocellular carcinoma. Gastroenterology. 1994 Aug;107(2):486–491. doi: 10.1016/0016-5085(94)90175-9. [DOI] [PubMed] [Google Scholar]
  5. Calvet X., Bruix J., Brú C., Ginés P., Vilana R., Solé M., Ayuso M. C., Bruguera M., Rodes J. Natural history of hepatocellular carcinoma in Spain. Five year's experience in 249 cases. J Hepatol. 1990 May;10(3):311–317. doi: 10.1016/0168-8278(90)90138-h. [DOI] [PubMed] [Google Scholar]
  6. Castells A., Bruix J., Bru C., Fuster J., Vilana R., Navasa M., Ayuso C., Boix L., Visa J., Rodés J. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology. 1993 Nov;18(5):1121–1126. [PubMed] [Google Scholar]
  7. Cottone M., Virdone R., Fusco G., Orlando A., Turri M., Caltagirone M., Maringhini A., Sciarrino E., Demma I., Nicoli N. Asymptomatic hepatocellular carcinoma in Child's A cirrhosis. A comparison of natural history and surgical treatment. Gastroenterology. 1989 Jun;96(6):1566–1571. doi: 10.1016/0016-5085(89)90528-3. [DOI] [PubMed] [Google Scholar]
  8. Farmer D. G., Rosove M. H., Shaked A., Busuttil R. W. Current treatment modalities for hepatocellular carcinoma. Ann Surg. 1994 Mar;219(3):236–247. doi: 10.1097/00000658-199403000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Franco D., Capussotti L., Smadja C., Bouzari H., Meakins J., Kemeny F., Grange D., Dellepiane M. Resection of hepatocellular carcinomas. Results in 72 European patients with cirrhosis. Gastroenterology. 1990 Mar;98(3):733–738. [PubMed] [Google Scholar]
  10. Gozzetti G., Mazziotti A., Cavallari A., Bellusci R., Bolondi L., Grigioni W., Bragaglia R., Grazi G. L., De Raffele E. Clinical experience with hepatic resections for hepatocellular carcinoma in patients with cirrhosis. Surg Gynecol Obstet. 1988 Jun;166(6):503–510. [PubMed] [Google Scholar]
  11. Izumi R., Shimizu K., Ii T., Yagi M., Matsui O., Nonomura A., Miyazaki I. Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology. 1994 Mar;106(3):720–727. doi: 10.1016/0016-5085(94)90707-2. [DOI] [PubMed] [Google Scholar]
  12. Makuuchi M., Hasegawa H., Yamazaki S., Takayasu K., Moriyama N. The use of operative ultrasound as an aid to liver resection in patients with hepatocellular carcinoma. World J Surg. 1987 Oct;11(5):615–621. doi: 10.1007/BF01655837. [DOI] [PubMed] [Google Scholar]
  13. Makuuchi M., Hasegawa H., Yamazaki S. Ultrasonically guided subsegmentectomy. Surg Gynecol Obstet. 1985 Oct;161(4):346–350. [PubMed] [Google Scholar]
  14. Matsumata T., Kanematsu T., Takenaka K., Yoshida Y., Nishizaki T., Sugimachi K. Patterns of intrahepatic recurrence after curative resection of hepatocellular carcinoma. Hepatology. 1989 Mar;9(3):457–460. doi: 10.1002/hep.1840090320. [DOI] [PubMed] [Google Scholar]
  15. Nagao T., Inoue S., Goto S., Mizuta T., Omori Y., Kawano N., Morioka Y. Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis. Ann Surg. 1987 Jan;205(1):33–40. doi: 10.1097/00000658-198701000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nagasue N., Uchida M., Makino Y., Takemoto Y., Yamanoi A., Hayashi T., Chang Y. C., Kohno H., Nakamura T., Yukaya H. Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology. 1993 Aug;105(2):488–494. doi: 10.1016/0016-5085(93)90724-q. [DOI] [PubMed] [Google Scholar]
  17. Nakashima T., Okuda K., Kojiro M., Jimi A., Yamaguchi R., Sakamoto K., Ikari T. Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years. Cancer. 1983 Mar 1;51(5):863–877. doi: 10.1002/1097-0142(19830301)51:5<863::aid-cncr2820510520>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  18. Okada S., Shimada K., Yamamoto J., Takayama T., Kosuge T., Yamasaki S., Sakamoto M., Hirohashi S. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology. 1994 Jun;106(6):1618–1624. doi: 10.1016/0016-5085(94)90419-7. [DOI] [PubMed] [Google Scholar]
  19. Okuda K. Early recognition of hepatocellular carcinoma. Hepatology. 1986 Jul-Aug;6(4):729–738. doi: 10.1002/hep.1840060432. [DOI] [PubMed] [Google Scholar]
  20. Pugh R. N., Murray-Lyon I. M., Dawson J. L., Pietroni M. C., Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973 Aug;60(8):646–649. doi: 10.1002/bjs.1800600817. [DOI] [PubMed] [Google Scholar]
  21. Ringe B., Pichlmayr R., Wittekind C., Tusch G. Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg. 1991 Mar-Apr;15(2):270–285. doi: 10.1007/BF01659064. [DOI] [PubMed] [Google Scholar]

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