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. 1996 Jul;64(7):2846–2849. doi: 10.1128/iai.64.7.2846-2849.1996

Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.

A Vecchiarelli 1, C Retini 1, C Monari 1, C Tascini 1, F Bistoni 1, T R Kozel 1
PMCID: PMC174153  PMID: 8698522

Abstract

In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.

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Selected References

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