Abstract
Background/Purpose: Up to 2.5% of newborn infants are cytomegalovirus (CMV) positive at birth. Five percent will be symptomatic at birth, including cytomegalic inclusion disease. Symptoms such as hearing loss and mental retardation will ultimately develop in 15%.
Methods: The authors describe a case of CMV enteritis in a 2.2-kg newborn that presented as necrotizing enterocolitis (NEC) and subsequently developed a colonic stricture.
Results: There are four reports of neonatal CMV enteritis in the nonEnglish-language literature. Cytomegalovirus enteritis has become prevalent among the immunosuppressed pediatric and adult patient population.
Conclusions: We propose the addition of CMV to the list of pathogens responsible for NEC. A review of neonatal CMV infection is provided.
Footnotes
Presented at the 30th Annual Meeting of the Pacific Association of Pediatric Surgeons, Phoenix, Arizona, May 9–13, 1997.
References
- 1.Stagno S, Pass RF, Dworsky ME. Congenital and perinatal cytomegalovirus infections. Semin Perinatol. 1983;7:31–42. [PubMed] [Google Scholar]
- 2.Dworsky M, Yow M, Stagno S. Cytomegalovirus infection of breast milk and transmission in infancy. Pediatrics. 1983;72:295–299. [PubMed] [Google Scholar]
- 3.de Cates CR, Gray J, Roberton NRC. Acquisition of cytomegalovirus infection by premature neonates. J Infect. 1994;28:25–30. doi: 10.1016/s0163-4453(94)94037-1. [DOI] [PubMed] [Google Scholar]
- 4.Oski FA, Sanchez PJ, Siegel JD. ed 2. JB Lippincott Co; Philadelphia, PA: 1994. pp. 540–543. (Principle and Practice of Pediatrics). [Google Scholar]
- 5.Rudolf A, Spector SA. ed 20. Appleton and Lange; Stamford, CT: 1996. Pediatrics; pp. 629–633. [Google Scholar]
- 6.Fletcher BA, Williams MK, Mulivoe RA. Intrauterine cytomegalovirus infection presenting as fetal meconium peritonitis. Obstet Gynecol. Nov 1991;78:903–905. [PubMed] [Google Scholar]
- 7.Gretillat F, Debray P, Mselati JC. Cytomegalic inclusions in the gastrointestinal tract of an infant with enterocolitis. Nouvelle Presse Medicale. 1979;8:2757. [PubMed] [Google Scholar]
- 8.Sann L, Aymard M, Gibert R. Necrotizing enterocolitis and cytomegalovirus infection. Nouvelle Presse Medicale. 1981;10:2495–2499. [PubMed] [Google Scholar]
- 9.D'Agostino S, Stracca-Pansa V, Drei F. Post-necrotizing enterocolitis stenosis of the colon associated with cytomegalovirus infection. Description of a clinical case. Pediatr Med Chir. 1988;10:637–639. [PubMed] [Google Scholar]
- 10.Fournier V, Gallet S, Feboud P. Ulcero-necrotizing enterocolitis: The role of cytomegalovirus. Apropos Pediatrie. 1989;44:189–192. [PubMed] [Google Scholar]
- 11.Schwartz DL, So HB, Bungarz WR. A case of life-threatening gastrointestinal hemorrhage in an infant with AIDS. J Pediatr Surg. 1989;24:313–315. doi: 10.1016/s0022-3468(89)80023-5. [DOI] [PubMed] [Google Scholar]
- 12.Dolgin SE, Larsen JG, Kumudini DS. CMV enteritis causing hemorrhage and obstruction in an infant with AIDS. J Pediatr Surg. 1990;25:696–698. doi: 10.1016/0022-3468(90)90369-k. [DOI] [PubMed] [Google Scholar]
- 13.Mellon A, Shepherd RW, Faoagali JL. Cytomegalovirus infection after liver transplantation in children. J Gastroenterol Hepatol. 1993;8:540–544. doi: 10.1111/j.1440-1746.1993.tb01649.x. [DOI] [PubMed] [Google Scholar]
- 14.Ashcraft KW, Holder TM, Amoury RA. ed 2. WB Saunders; Philadelphia, PA: 1993. p. 343. (Pediatric Surgery). [Google Scholar]