Abstract
We conducted a population-based case-control study to evaluate the relationship between cases of breast cancer and exposure to tetrachloroethylene (PCE) from public drinking water ( n = 258 cases and 686 controls). Women were exposed to PCE when it leached from the vinyl lining of water distribution pipes. The relative delivered dose was estimated using an algorithm that accounted for residential history, water flow, and pipe characteristics. Only small increases in breast cancer risk were seen among ever-exposed women either when latency was ignored or when 5 to 15 years of latency was considered. No or small increases were seen among highly exposed women either when latency was ignored or when 5 years of latency was considered. However, the adjusted odds ratios (ORs) were more increased for highly exposed women when 7 and 9 years of latency, respectively, were considered (OR 1.5 95% CI 0.5-4.7 and OR 2.3, 95% CI 0.6-8.8 for the 75th percentile, and OR 2.7, 95% CI 0.4-15.8 and OR 7.6, 95% CI 0.9-161.3 for the 90th percentile). The number of highly exposed women was too small for meaningful analysis when more years of latency were considered. Because firm conclusions from these data are limited, we recently undertook a new study with a large number of more recently diagnosed cases.
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- Aschengrau A., Ozonoff D., Coogan P., Vezina R., Heeren T., Zhang Y. Cancer risk and residential proximity to cranberry cultivation in Massachusetts. Am J Public Health. 1996 Sep;86(9):1289–1296. doi: 10.2105/ajph.86.9.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aschengrau A., Ozonoff D., Paulu C., Coogan P., Vezina R., Heeren T., Zhang Y. Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts. Arch Environ Health. 1993 Sep-Oct;48(5):284–292. doi: 10.1080/00039896.1993.9936715. [DOI] [PubMed] [Google Scholar]
- Blair A., Decoufle P., Grauman D. Causes of death among laundry and dry cleaning workers. Am J Public Health. 1979 May;69(5):508–511. doi: 10.2105/ajph.69.5.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blair A., Stewart P. A., Tolbert P. E., Grauman D., Moran F. X., Vaught J., Rayner J. Cancer and other causes of death among a cohort of dry cleaners. Br J Ind Med. 1990 Mar;47(3):162–168. doi: 10.1136/oem.47.3.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duh R. W., Asal N. R. Mortality among laundry and dry cleaning workers in Oklahoma. Am J Public Health. 1984 Nov;74(11):1278–1280. doi: 10.2105/ajph.74.11.1278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hatten J. Medicare's common denominator: the covered population. Health Care Financ Rev. 1980 Fall;2(2):53–64. [PMC free article] [PubMed] [Google Scholar]
- Katz R. M., Jowett D. Female laundry and dry cleaning workers in Wisconsin: a mortality analysis. Am J Public Health. 1981 Mar;71(3):305–307. doi: 10.2105/ajph.71.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ozonoff D., Aschengrau A., Coogan P. Cancer in the vicinity of a Department of Defense superfund site in Massachusetts. Toxicol Ind Health. 1994 May-Jun;10(3):119–141. doi: 10.1177/074823379401000302. [DOI] [PubMed] [Google Scholar]
- Ruder A. M., Ward E. M., Brown D. P. Cancer mortality in female and male dry-cleaning workers. J Occup Med. 1994 Aug;36(8):867–874. [PubMed] [Google Scholar]
- Soto A. M., Sonnenschein C., Chung K. L., Fernandez M. F., Olea N., Serrano F. O. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect. 1995 Oct;103 (Suppl 7):113–122. doi: 10.1289/ehp.95103s7113. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webler T., Brown H. S. Exposure to tetrachloroethylene via contaminated drinking water pipes in Massachusetts: a predictive model. Arch Environ Health. 1993 Sep-Oct;48(5):293–297. doi: 10.1080/00039896.1993.9936716. [DOI] [PubMed] [Google Scholar]