Abstract
Synovial fluids (83.3%) from patients with rheumatoid arthritis gave a positive reaction when examined by immunodiffusion against a Lancefield extract of Group A Type 12 streptococci. None of the patients with osteoarthrosis reacted positively. An antiserum was prepared to the material in synovial fluid reacting with the streptococcal extract. This antiserum reacted positively with all synovial fluids tested including the osteoarthrosis patients. It also reacted with all plasma samples tested but only with a few (18.2%) of serum samples. Immunodiffusion and absorption experiments demonstrated that the material reacting with the streptococcal extract was fibrinogen. Of 12 other streptococci examined only one, a Group C organism, gave a similar positive reaction with synovial fluids.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Braun D. G., Holm S. E. Streptococcal anti-group A precipitins in sera from patients with rheumatic arthritis and acute glomerulonephritis. Int Arch Allergy Appl Immunol. 1970;37(2):216–224. doi: 10.1159/000230234. [DOI] [PubMed] [Google Scholar]
- SCHUR P. H., SANDSON J. Immunologic studies of the proteins of human synovial fluid. Arthritis Rheum. 1963 Apr;6:115–129. doi: 10.1002/art.1780060204. [DOI] [PubMed] [Google Scholar]
- Stein H., Yarom R., Levin S., Dishon T., Ginsburg I., Harris T. N. Chronic self-perpetuating arthritis induced in rabbits by a cell-free extract of group A streptococci. Proc Soc Exp Biol Med. 1973 Sep;143(4):1106–1112. doi: 10.3181/00379727-143-37479. [DOI] [PubMed] [Google Scholar]
- Stewart S. M., Alexander W. R., Duthie J. J. Isolation of diphtheroid bacilli from synovial membrane and fluid in rheumatoid arthritis. Ann Rheum Dis. 1969 Sep;28(5):477–487. doi: 10.1136/ard.28.5.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takeda Y. Studies of the metabolism and distribution of fibrinogen in patients with rheumatoid arthritis. J Lab Clin Med. 1967 Apr;69(4):624–633. [PubMed] [Google Scholar]