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. 1976 Sep;49(4):317–325.

Interaction between Bronchoconstrictor Stimuli on Human Airway Smooth Muscle 1

Charles Mitchell, Arend Bouhuys
PMCID: PMC2595490  PMID: 997592

Abstract

In healthy human subjects, the simultaneous aerosol administration of histamine and methacholine results in a pronounced decrease in maximum flow rates on partial expiratory flow-volume (PEFV) curves. When given alone in the same concentrations, these drugs produced no or minimal decreases in flow rates. The results suggest an interaction of histamine and cholinergic stimuli on airway smooth muscle (ASM). This mechanism might explain many experiments where vagal blockade diminished or abolished ASM response to histamine and other stimuli, simply by interfering with histamine-cholinergic interaction at the ASM level. These findings confirm similar findings of animal in vitro experiments. The experiments clearly confirm the sensitivity and value of assessing drug effects prior to a deep breath. Flow-rate changes after a full inspiration, taken from the maximum expiratory flow-volume (MEFV) curve, show either no relationship to the concentration of inhaled methacholine or significantly less effect than that seen on the PEFV curve.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARBORELIUS M., Jr, EKWALL B., JERNERUS R., LUNDIN G., SVANBERG L. Unilateral provoked bronchial asthma in man. J Clin Invest. 1962 Jun;41:1236–1241. doi: 10.1172/JCI104585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bevan J. A. Tonically active vagal pulmonary afferent neurones. Life Sci. 1965 Dec;4(23):2289–2294. doi: 10.1016/0024-3205(65)90251-1. [DOI] [PubMed] [Google Scholar]
  3. Bouhuys A., Jonson B. Alveolar pressure, airflow rate, and lung inflation in man. J Appl Physiol. 1967 Jun;22(6):1086–1100. doi: 10.1152/jappl.1967.22.6.1086. [DOI] [PubMed] [Google Scholar]
  4. Bouhuys A., Mitchell C. A., Schilling R. S., Zuskin E. A physiological study of byssinosis in colonial America. Trans N Y Acad Sci. 1973 Nov;35(7):537–546. doi: 10.1111/j.2164-0947.1973.tb01526.x. [DOI] [PubMed] [Google Scholar]
  5. DeKock M. A., Nadel J. A., Zwi S., Colebatch H. J., Olsen C. R. New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J Appl Physiol. 1966 Jan;21(1):185–194. doi: 10.1152/jappl.1966.21.1.185. [DOI] [PubMed] [Google Scholar]
  6. Douglas J. S., Dennis M. W., Ridgway P., Bouhuys A. Airway constriction in guinea pigs: interaction of histamine and autonomic drugs. J Pharmacol Exp Ther. 1973 Jan;184(1):169–179. [PubMed] [Google Scholar]
  7. Gold W. M., Kessler G. F., Yu D. Y. Role of vagus nerves in experimental asthma in allergic dogs. J Appl Physiol. 1972 Dec;33(6):719–725. doi: 10.1152/jappl.1972.33.6.719. [DOI] [PubMed] [Google Scholar]
  8. Karczewski W., Widdicombe J. G. The role of the vagus nerves in the respiratory and circulatory responses to intravenous histamine and phenyl diguanide in rabbits. J Physiol. 1969 Apr;201(2):271–291. doi: 10.1113/jphysiol.1969.sp008755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mills J. E., Widdicombe J. G. Role of the vagus nerves in anaphylaxis and histamine-induced bronchoconstrictions in guinea-pigs. Br J Pharmacol. 1970 Aug;39(4):724–731. doi: 10.1111/j.1476-5381.1970.tb09898.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. NADEL J. A., TIERNEY D. F. Effect of a previous deep inspiration on airway resistance in man. J Appl Physiol. 1961 Jul;16:717–719. doi: 10.1152/jappl.1961.16.4.717. [DOI] [PubMed] [Google Scholar]
  11. SCHILD H. O., HAWKINS D. F., MONGAR J. L., HERXHEIMER H. Reactions of isolated human asthmatic lung and bronchial tissue to a specific antigen; histamine release and muscular contraction. Lancet. 1951 Sep 1;2(6679):376–382. doi: 10.1016/s0140-6736(51)91554-1. [DOI] [PubMed] [Google Scholar]
  12. Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov;46(11):1812–1818. doi: 10.1172/JCI105671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Vincent N. J., Knudson R., Leith D. E., Macklem P. T., Mead J. Factors influencing pulmonary resistance. J Appl Physiol. 1970 Aug;29(2):236–243. doi: 10.1152/jappl.1970.29.2.236. [DOI] [PubMed] [Google Scholar]
  14. Virgulto J., Bouhuys A. Electronic circuits for recording of maximum expiratory flow-volume (MEFV) curves. J Appl Physiol. 1973 Jul;35(1):145–147. doi: 10.1152/jappl.1973.35.1.145. [DOI] [PubMed] [Google Scholar]
  15. Zuskin E., Mitchell C. A., Bouhuys A. Interaction between effects of beta blockade and cigarette smoke on airways. J Appl Physiol. 1974 Apr;36(4):449–452. doi: 10.1152/jappl.1974.36.4.449. [DOI] [PubMed] [Google Scholar]
  16. de VRIES, GOEI J. T., BOOY-NOORD H., ORIE N. G. Changes during 24 hours in the lung function and histamine hyperreactivity of the bronchial tree in asthmatic and bronchitic patients. Int Arch Allergy Appl Immunol. 1962;20:93–101. doi: 10.1159/000229248. [DOI] [PubMed] [Google Scholar]

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