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. 1978 Aug;37(4):357–362. doi: 10.1136/ard.37.4.357

Brain scan diagnosis of central nervous system involvement in systemic lupus erythematosus.

R F Tan, D D Gladman, M B Urowitz, N Milne
PMCID: PMC1000244  PMID: 686868

Abstract

Twenty-five patients with 29 episodes of active systemic lupus erythematosus with central nervous system involvement were studied according to a uniform protocol. Brain scans were found to be abnormal in all patients studied, and electroencephalograms were abnormal in 20/25 patients. Serial brain scanning was found to be useful in the diagnosis of exacerbations and the monitoring of corticosteroid dosage.

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Selected References

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  1. Atkins C. J., Kondon J. J., Quismorio F. P., Friou G. J. The choroid plexus in systemic lupus erythematosus. Ann Intern Med. 1972 Jan;76(1):65–72. doi: 10.7326/0003-4819-76-1-65. [DOI] [PubMed] [Google Scholar]
  2. Bennahum D. A., Messner R. P. Recent observations on central nervous system lupus erythematosus. Semin Arthritis Rheum. 1975 Feb;4(3):253–266. doi: 10.1016/0049-0172(75)90012-8. [DOI] [PubMed] [Google Scholar]
  3. Bennahum D. A., Messner R. P., Shoop J. D. Brain scan findings in central nervous system involvement by lupus erythematosus. Ann Intern Med. 1974 Dec;81(6):763–765. doi: 10.7326/0003-4819-81-6-763. [DOI] [PubMed] [Google Scholar]
  4. Estes D., Christian C. L. The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 1971 Mar;50(2):85–95. doi: 10.1097/00005792-197103000-00001. [DOI] [PubMed] [Google Scholar]
  5. Feinglass E. J., Arnett F. C., Dorsch C. A., Zizic T. M., Stevens M. B. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 1976 Jul;55(4):323–339. doi: 10.1097/00005792-197607000-00004. [DOI] [PubMed] [Google Scholar]
  6. Gibson T., Myers A. R. Nervous system involvement in systemic lupus erythematosus. Ann Rheum Dis. 1975 Oct;35(5):398–406. doi: 10.1136/ard.35.5.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HARVEY A. M., SHULMAN L. E., TUMULTY P. A., CONLEY C. L., SCHOENRICH E. H. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 1954 Dec;33(4):291–437. [PubMed] [Google Scholar]
  8. Hadler N. M., Gerwin R. D., Frank M. M., Whitaker J. N., Baker M., Decker J. L. The fourth component of complement in the cerebrospinal fluid in systemic Lupus erythematosus. Arthritis Rheum. 1973 Jul-Aug;16(4):507–521. doi: 10.1002/art.1780160411. [DOI] [PubMed] [Google Scholar]
  9. Johnson R. T., Richardson E. P. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore) 1968 Jul;47(4):337–369. doi: 10.1097/00005792-196807000-00002. [DOI] [PubMed] [Google Scholar]
  10. Lee P., Urowitz M. B., Bookman A. A., Koehler B. E., Smythe H. A., Gordon D. A., Ogryzlo M. A. Systemic lupus erythematosus. A review of 110 cases with reference to nephritis, the nervous system, infections, aseptic necrosis and prognosis. Q J Med. 1977 Jan;46(181):1–32. [PubMed] [Google Scholar]
  11. Petz L. D., Sharp G. C., Cooper N. R., Irvin W. S. Serum and cerebral spinal fluid complement and serum autoantibodies in systemic lupus erythematosus. Medicine (Baltimore) 1971 Jul;50(4):259–275. doi: 10.1097/00005792-197107000-00002. [DOI] [PubMed] [Google Scholar]
  12. Sergent J. S., Lockshin M. D., Klempner M. S., Lipsky B. A. Central nervous system disease in systemic lupus erythematosus. Therapy and prognosis. Am J Med. 1975 May;58(5):644–654. doi: 10.1016/0002-9343(75)90500-8. [DOI] [PubMed] [Google Scholar]
  13. Small P., Mass M. F., Kohler P. F., Harbeck R. J. Central nervous system involvement in SLE. Diagnostic profile and clinical features. Arthritis Rheum. 1977 Apr;20(3):869–878. doi: 10.1002/art.1780200317. [DOI] [PubMed] [Google Scholar]

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