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. 1978 Dec;37(6):552–556. doi: 10.1136/ard.37.6.552

The effect of zinc on alkaline phosphatase activity in rheumatoid synovial tissue.

J J Johnstone, L Bitensky, B Cashman, J Chayen
PMCID: PMC1000294  PMID: 749701

Abstract

To examine the reported beneficial effect of zinc in rheumatoid arthritis, rheumatoid synovial tissue has been maintained in vitro in non-proliferative culture with or without zinc sulphate in the culture medium. Alkaline phosphatase activity was measured by microdensitometry of the cytochemical reaction in cryostat sections; the activity in blood vessels was measured separately from that in the supporting tissue below the synovial surface. Zinc enhanced this activity optimally at concentrations of between 10(-5) and 10(-4) mol/l.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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