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. 1980 Feb;39(1):37–44. doi: 10.1136/ard.39.1.37

Faecal carriage of klebsiella by patients with ankylosing spondylitis and rheumatoid arthritis.

R E Warren, D A Brewerton
PMCID: PMC1000467  PMID: 7377857

Abstract

In consecutive samples submitted to a clinical microbiology laboratory 22 out of 99 from outpatients and 23 out of 51 from inpatients yielded Klebsiella sp. A clinical reassessment of outpatients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) who had not been inpatients within the last year was made for disease activity and drug requirements. 124 patients with AS and 92 with RA were requested at assessment to submit a stool specimen for klebsiella examination, this being carried out without disclosure of the patient's clinical category. Two months later a questionnaire on symptom changes was collected and the results correlated with klebsiella carriage. Eighty-nine patients with AS and 82 patients with RA fulfilled all criteria for assessment. Of those assessed, 24 out of 89 AS patients and 26 out of 82 RA patients had klebsiella in the faeces. There was no correlation betweeh the initial clinical assessment category and klebsiella carriage. Seventy patients with AS and 57 paients with RA had no change in symptoms over the 2-month period. Nineteen AS patients and 31 RA patients noted symptom improvement or worsening. Of these, 3 AS and 10 RA patients had klebsiella in their faeces. There was no correlation between worsening of symptoms over a 2-month period and klebsiella carriage at initial assessment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahvonen P. Human yersiniosis in Finland. I. Bacteriology and serology. Ann Clin Res. 1972 Feb;4(1):30–38. [PubMed] [Google Scholar]
  2. Ahvonen P., Sievers K., Aho K. Arthritis associated with Yersinia enterocolitica infection. Acta Rheumatol Scand. 1969;15(3):232–253. doi: 10.3109/rhe1.1969.15.issue-1-4.32. [DOI] [PubMed] [Google Scholar]
  3. Barua D., Watanabe Y. Vibriocidal antibodies induced by Yersinia enterocolitica serotype IX. J Hyg (Lond) 1972 Mar;70(1):161–169. doi: 10.1017/s0022172400022208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Casewell M. W., Phillips I. Epidemiological patterns of Klebsiella colonization and infection in an intensive care ward. J Hyg (Lond) 1978 Apr;80(2):295–300. doi: 10.1017/s0022172400053651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Casewell M., Phillips I. Food as a source of Klebsiella species for colonisation and infection of intensive care patients. J Clin Pathol. 1978 Sep;31(9):845–849. doi: 10.1136/jcp.31.9.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chalmers A., Kaprove R. E., Reynolds W. J., Urowitz M. B. Postdiarrheal arthropathy of Yersinia pseudotuberculosis. Can Med Assoc J. 1978 Mar 4;118(5):515–516. [PMC free article] [PubMed] [Google Scholar]
  7. DAVIES D. A. Dideoxysugars of Pasteurella pseudotuberculosis-specific polysaccharides, and the occurrence of ascarylose. Nature. 1961 Jul 1;191:43–44. doi: 10.1038/191043a0. [DOI] [PubMed] [Google Scholar]
  8. DAVIES D. A. The smooth and rough somatic antigens of Pasteurella pseudotuberculosis. J Gen Microbiol. 1958 Feb;18(1):118–128. doi: 10.1099/00221287-18-1-118. [DOI] [PubMed] [Google Scholar]
  9. Datta N. Drug resistance and R factors in the bowel bacteria of London patients before and after admission to hospital. Br Med J. 1969 May 17;2(5654):407–411. doi: 10.1136/bmj.2.5654.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ebringer R., Cooke D., Cawdell D. R., Cowling P., Ebringer A. Ankylosing spondylitis: klebsiella and HL-A B27. Rheumatol Rehabil. 1977 Aug;16(3):190–196. doi: 10.1093/rheumatology/16.3.190. [DOI] [PubMed] [Google Scholar]
  12. Feeley J. C. Somatic O antigen relationship of Brucella and Vibrio cholerae. J Bacteriol. 1969 Sep;99(3):645–649. doi: 10.1128/jb.99.3.645-649.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Good A. E., Schultz J. S. Reiter's syndrome following Shigella flexneri 2a: a sequel to traveler's diarrhea. Report of a case with hepatitis. Arthritis Rheum. 1977 Jan-Feb;20(1):100–104. doi: 10.1002/art.1780200117. [DOI] [PubMed] [Google Scholar]
  14. HENRIKSEN S. D. Studies on the Klebsiella group (Kauffmann). IV. Cross-reactions of Klebsiella types 8, 11, 21, 26 and 35, and the M-antigen of Escherichia coli. Acta Pathol Microbiol Scand. 1954;34(3):271–275. [PubMed] [Google Scholar]
  15. Hartley C. L., Clements H. M., Linton K. B. Escherichia coli in the faecal flora of man. J Appl Bacteriol. 1977 Oct;43(2):261–269. doi: 10.1111/j.1365-2672.1977.tb00750.x. [DOI] [PubMed] [Google Scholar]
  16. Hodinka L., Gömör B., Merétey K., Zahumenszky Z., Géher P., Telegdy L., Bozsóky S. HLA-B27-associated spondylarthritis in chronic brucellosis. Lancet. 1978 Mar 4;1(8062):499–499. doi: 10.1016/s0140-6736(78)90158-7. [DOI] [PubMed] [Google Scholar]
  17. Hurvell B., Ahvonen P., Thal E. Serological cross-reactions between different Brucella species and Yersinia enterocolitica. Agglutination and complement fixation. Acta Vet Scand. 1971;12(1):86–94. [PubMed] [Google Scholar]
  18. Maeland J. A., Digranes A. Common enterobacterial antigen in Yersinia enterocolitica. Acta Pathol Microbiol Scand B. 1975 Aug;83(4):382–386. doi: 10.1111/j.1699-0463.1975.tb00116.x. [DOI] [PubMed] [Google Scholar]
  19. Montgomerie J. Z., Doak P. B., Taylor D. E., North J. D., Martin W. J. Klebsiella in faecal flora of renal-transplant patients. Lancet. 1970 Oct 17;2(7677):787–792. doi: 10.1016/s0140-6736(70)91458-3. [DOI] [PubMed] [Google Scholar]
  20. Orskov I., Orskov F., Jann B., Jann K. Serology, chemistry, and genetics of O and K antigens of Escherichia coli. Bacteriol Rev. 1977 Sep;41(3):667–710. doi: 10.1128/br.41.3.667-710.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Selden R., Lee S., Wang W. L., Bennett J. V., Eickhoff T. C. Nosocomial klebsiella infections: intestinal colonization as a reservoir. Ann Intern Med. 1971 May;74(5):657–664. doi: 10.7326/0003-4819-74-5-657. [DOI] [PubMed] [Google Scholar]
  22. VARTIAINEN J., HURRI L. ARTHRITIS DUE TO SALMONELLA TYPHIMURIUM. REPORT OF 12 CASES OF MIGRATORY ARTHRITIS IN ASSOCIATION WITH SALMONELLA TYPHIMURIUM INFECTION. Acta Med Scand. 1964 Jun;175:771–776. [PubMed] [Google Scholar]
  23. Warren C. P. Arthritis associated with Salmonella infections. Ann Rheum Dis. 1970 Sep;29(5):483–487. doi: 10.1136/ard.29.5.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wauters G., Le Minor L., Chalon A. M. Antigènes somatiques et flagellaires des Yersinia enterocolitica. Ann Inst Pasteur (Paris) 1971 May;120(5):631–642. [PubMed] [Google Scholar]
  25. Winkle S., Refai M., Rohde R. On the antigenic relationship of "Vibrio cholerae" to "Enterobacteriaceae". Ann Inst Pasteur (Paris) 1972 Dec;123(6):775–781. [PubMed] [Google Scholar]
  26. ØRSKOV I. O antigens in the Klebsiella group. Acta Pathol Microbiol Scand. 1954;34(2):145–156. doi: 10.1111/j.1699-0463.1954.tb00811.x. [DOI] [PubMed] [Google Scholar]

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