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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1981 Feb;40(1):92–95. doi: 10.1136/ard.40.1.92

Hepatocellular disease in the giant-cell arteritis/polymyalgia rheumatica syndrome.

A S Leong, M H Alp
PMCID: PMC1000666  PMID: 7469532

Abstract

An elderly man developed temporal arteritis and polymyalgia rheumatica with coexisting biochemical abnormalities of liver function. Biopsy revealed hepatic changes which have not been previously reported. There was hepatocellular necrosis and inflammation together with a prominent hyperplasia of perisinusoidal lipocytes of Ito. Temporal artery biopsy confirmed the presence of granulomatous panarteritis. Corticosteroid therapy produced rapid resolution of symptoms and reversion of liver function tests to normal.

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Selected References

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  1. BARBER H. S. Myalgic syndrome with constitutional effects; polymyalgia rheumatica. Ann Rheum Dis. 1957 Jun;16(2):230–237. doi: 10.1136/ard.16.2.230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bacon P. A., Doherty S. M., Zuckerman A. J. Hepatitis-B antibody in polymyalgia Rheumatica. Lancet. 1975 Sep 13;2(7933):476–478. doi: 10.1016/s0140-6736(75)90547-4. [DOI] [PubMed] [Google Scholar]
  3. Dickson E. R., Maldonado J. E., Sheps S. G., Cain J. A., Jr Systemic giant-cell arteritis with polymyalgia rheumatica, reversible abnormalities of liver function. JAMA. 1973 Jun 11;224(11):1496–1498. [PubMed] [Google Scholar]
  4. Hamilton C. R., Jr, Shelley W. M., Tumulty P. A. Giant cell arteritis: including temporal arteritis and polymyalgia rheumatica. Medicine (Baltimore) 1971 Jan;50(1):1–27. [PubMed] [Google Scholar]
  5. Healey L. A., Wilske K. R. Manifestations of giant cell arteritis. Med Clin North Am. 1977 Mar;61(2):261–270. doi: 10.1016/s0025-7125(16)31331-1. [DOI] [PubMed] [Google Scholar]
  6. Hopwood D., Nyfors A. Effect of methotrexate therapy in psoriatics on the Ito cells in liver biopsies, assessed by point-counting. J Clin Pathol. 1976 Aug;29(8):698–703. doi: 10.1136/jcp.29.8.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hruban Z., Russell R. M., Boyer J. L., Glagov S., Bagheri S. A. Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol. 1974 Sep;76(3):451–461. [PMC free article] [PubMed] [Google Scholar]
  8. Liang G. C., Simkin P. A., Mannik M. Immunoglobulins in temporal arteries. An immunofluorescent study. Ann Intern Med. 1974 Jul;81(1):19–24. doi: 10.7326/0003-4819-81-1-19. [DOI] [PubMed] [Google Scholar]
  9. Malmvall B. E., Bengtsson B. A. Giant cell arteritis. Clinical features and involvement of different organs. Scand J Rheumatol. 1978;7(3):154–158. doi: 10.3109/03009747809095645. [DOI] [PubMed] [Google Scholar]
  10. Rynes R. I., Mika P., Bartholomew L. E. Development of giant cell (temporal) arteritis in a patient 'adequately' treated for polymyalgia rheumatica. Ann Rheum Dis. 1977 Feb;36(1):88–90. doi: 10.1136/ard.36.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. von Knorring J., Wassatjerna C. Liver involvement in polymyalgia rheumatica. Scand J Rheumatol. 1976;5(4):197–204. doi: 10.3109/03009747609099905. [DOI] [PubMed] [Google Scholar]

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