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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1982 Feb;41(1):86–89. doi: 10.1136/ard.41.1.86

The in-vivo metabolism of C3 in ankylosing spondylitis.

L Brinch, O Vinje, P Teisberg, O J Mellbye, I Aakesson
PMCID: PMC1000870  PMID: 7065734

Abstract

Turnover studies with radioactively labelled C3 were performed in 7 patients with ankylosing spondylitis and in 14 healthy individuals .As a group the patients had a moderately higher fractional catabolic rate of C3 than the controls. A possible explanation is that the complement system is activated by immune complexes. The serum levels of C3 were high. The hypercatabolism was therefore more than compensated for by an increased synthesis rate.

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Selected References

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  1. Brinch L., Aakesson I. Aseptic isolation of human complement component C3 for in vivo studies. Scand J Clin Lab Invest. 1980 Sep;40(5):487–489. doi: 10.3109/00365518009101873. [DOI] [PubMed] [Google Scholar]
  2. Brinch L., Teisberg P., Aakesson I. Metabolic studies of C3 in man. J Immunol Methods. 1979;30(1):69–75. doi: 10.1016/0022-1759(79)90274-6. [DOI] [PubMed] [Google Scholar]
  3. Brinch L., Teisberg P., Fausa O., Akesson I. The metabolism of C3 in adult coeliac disease. Scand J Gastroenterol. 1980;15(1):33–38. doi: 10.3109/00365528009181428. [DOI] [PubMed] [Google Scholar]
  4. Charlesworth J. A., Williams D. G., Sherington E., Lachmann P. J., Peters D. K. Metabolic studies of the third component of complement and the glycine-rich beta glycoprotein in patients with hypocomplementemia. J Clin Invest. 1974 Jun;53(6):1578–1587. doi: 10.1172/JCI107708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Corrigall V., Panayi G. S., Unger A., Poston R. N., Williams B. D. Detection of immune complexes in serum of patients with ankylosing spondylitis. Ann Rheum Dis. 1978 Apr;37(2):159–163. doi: 10.1136/ard.37.2.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duquesnoy B., Santoro F., Delcambre B., Wattre P. Absence de complexes immuns circulants et d'anticorps anti-IgG sériques au cours de la spondylarthrite ankylosante. Rev Rhum Mal Osteoartic. 1979 Jun;46(6):397–401. [PubMed] [Google Scholar]
  7. Gabay R., Zubler R. H., Nydegger U. E., Lambert P. H. Immune complexes and complement catabolism in ankylosing spondylitis. Arthritis Rheum. 1977 May;20(4):913–916. doi: 10.1002/art.1780200402. [DOI] [PubMed] [Google Scholar]
  8. Hodgson H. J., Potter B. J., Jewell D. P. C3 metabolism in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977 Jun;28(3):490–495. [PMC free article] [PubMed] [Google Scholar]
  9. Kinsella T. D., Espinoza L., Vasey F. B. Serum complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol. 1975 Sep;2(3):308–313. [PubMed] [Google Scholar]
  10. MATTHEWS C. M. The theory of tracer experiments with 131I-labelled plasma proteins. Phys Med Biol. 1957 Jul;2(1):36–53. doi: 10.1088/0031-9155/2/1/305. [DOI] [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. Petz L. D., Powers R., Fries J. R., Cooper N. R., Holman H. R. The in vivo metabolism of the third component of complement in systemic lupus erythematosus. Arthritis Rheum. 1977 Sep-Oct;20(7):1304–1313. doi: 10.1002/art.1780200702. [DOI] [PubMed] [Google Scholar]
  13. Potter B. J., Elias E., Jones E. A. Hypercatabolism of the third component of complement in patients with primary biliary cirrhosis. J Lab Clin Med. 1976 Sep;88(3):427–439. [PubMed] [Google Scholar]
  14. Thomas H. C., Potter B. J., Elias E., Sherlock S. Metabolism of the third component of complement in acute type B hepatitis, HBs antigen positive glomerulonephritis, polyarteritis nodosum, and HBs antigen positive and negative chronic active liver disease. Gastroenterology. 1979 Apr;76(4):673–679. [PubMed] [Google Scholar]
  15. Weinstein A., Peters K., Brown D., Bluestone R. Metabolism of the third component of complement (C3) in patients with rheumatoid arthritis. Arthritis Rheum. 1972 Jan-Feb;15(1):49–56. doi: 10.1002/art.1780150108. [DOI] [PubMed] [Google Scholar]
  16. Whaley K., Canesi B., Moseley A., Morrow W., Sturrock R., Mitchell W., Dick W. C. Complement metabolism in the seronegative arthritides. Ann Rheum Dis. 1974 Nov;33(6):495–499. doi: 10.1136/ard.33.6.495. [DOI] [PMC free article] [PubMed] [Google Scholar]

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