Abstract
Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating highlighted this finding. No difference was found in the phagocytic or adherent properties of PMN in Behçet's syndrome. Increased PMN motility in Behçet's syndrome may contribute to the expression of the syndrome. It remains to be tested whether altered PMN motility in this syndrome is genetically linked.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- DIOGUARDI N., AGOSTONI A., FIORELLI G., LOMANTO B. Characterization of lactic dehydrogenase of normal human granulocytes. J Lab Clin Med. 1963 May;61:713–723. [PubMed] [Google Scholar]
- Ferrante A., Thong Y. H. A rapid one-step procedure for purification of mononuclear and polymorphonuclear leukocytes from human blood using a modification of the Hypaque-Ficoll technique. J Immunol Methods. 1978;24(3-4):389–393. doi: 10.1016/0022-1759(78)90143-6. [DOI] [PubMed] [Google Scholar]
- James D. W., Walker J. R., Smith M. J. Abnormal polymorphonuclear leucocyte chemotaxis in Behçet's syndrome. Ann Rheum Dis. 1979 Jun;38(3):219–221. doi: 10.1136/ard.38.3.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lehrer R. I., Cline M. J. Interaction of Candida albicans with human leukocytes and serum. J Bacteriol. 1969 Jun;98(3):996–1004. doi: 10.1128/jb.98.3.996-1004.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leirisalo M., Repo H., Tiilikainen A., Kosunen T. U., Laitinen O. Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro. Arthritis Rheum. 1980 Sep;23(9):1036–1044. doi: 10.1002/art.1780230911. [DOI] [PubMed] [Google Scholar]
- Mason R. M., Barnes C. G. Behçet's syndrome with arthritis. Ann Rheum Dis. 1969 Mar;28(2):95–103. doi: 10.1136/ard.28.2.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matsumura N., Mizushima Y. Leucocyte movement and colchicine treatment in Behcet's disease. Lancet. 1975 Oct 25;2(7939):813–813. doi: 10.1016/s0140-6736(75)80031-6. [DOI] [PubMed] [Google Scholar]
- Orr W., Ward P. A. Quantitation of leukotaxis in agarose by three different methods. J Immunol Methods. 1978;20:95–107. doi: 10.1016/0022-1759(78)90248-x. [DOI] [PubMed] [Google Scholar]
- Repo H. Leukocyte migration agarose test for the assessment of human neutrophil chemotaxis. I. Effects of environmental factors on neutrophil migration under agarose. Scand J Immunol. 1977;6(3):203–209. doi: 10.1111/j.1365-3083.1977.tb00385.x. [DOI] [PubMed] [Google Scholar]
- Sobel J. D., Haim S., Obedeanu N., Meshulam T., Merzbach D. Polymorphonuclear leucocyte function in Behçet's disease. J Clin Pathol. 1977 Mar;30(3):250–253. doi: 10.1136/jcp.30.3.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stecher V. J., Chinea G. L. The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents. Agents Actions. 1978 Apr;8(3):258–262. doi: 10.1007/BF01966612. [DOI] [PubMed] [Google Scholar]
- Vernon-Roberts B., Barnes C. G., Revell P. A. Synovial pathology in Behcet's syndrome. Ann Rheum Dis. 1978 Apr;37(2):139–145. doi: 10.1136/ard.37.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ward P. A. The chemosuppression of chemotaxis. J Exp Med. 1966 Aug 1;124(2):209–226. doi: 10.1084/jem.124.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]