Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Apr;42(2):132–137. doi: 10.1136/ard.42.2.132

Yttrium-90 therapy and 99MTc pertechnetate knee uptake measurements in the management of rheumatoid arthritis.

V Kyle, B L Hazleman, E P Wraight
PMCID: PMC1001085  PMID: 6303231

Abstract

Twenty-eight knees with chronic arthritis and effusion were treated with intra-articular 90Y. Synovial activity was assessed by measuring 99mTc pertechnetate uptake. There was a significant difference in uptake between controls and patients. Those who had a good response to 90Y (15 patients) showed a significant decrease in uptake, not seen in those who failed to respond. The pattern of 90Y distribution was examined and appeared to correspond to areas of increased synovial activity; these patterns and their significance have not been previously reported. Factors which could help to predict response to 90Y are discussed.

Full text

PDF
136

Images in this article

134Image
on p.134
134Image
on p.134
134Image
on p.134
135Image
on p.135
135Image
on p.135

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANSELL B. M., CROOK A., MALLARD J. R., BYWATERS E. G. EVALUATION OF INTRA-ARTICULAR COLLOIDAL GOLD AU 198 IN THE TREATMENT OF PRESISTENT KNEE EFFUSIONS. Ann Rheum Dis. 1963 Nov;22:435–439. doi: 10.1136/ard.22.6.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bridgman J. F., Bruckner F., Eisen V., Tucker A., Bleehen N. M. Irradiation of the synovium in the treatment of rheumatoid arthritis. Q J Med. 1973 Apr;42(166):357–367. [PubMed] [Google Scholar]
  3. Dick W. C., Neufeld R. R., Prentice A. G., Woodburn A., Whaley K., Nuki G., Buchanan W. W. Measurement of joint inflammation. A radioisotopic method. Ann Rheum Dis. 1970 Mar;29(2):135–137. doi: 10.1136/ard.29.2.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dolphin G. W. Biological hazards of radiation. Ann Rheum Dis. 1973 Dec;32 (Suppl 6)(Suppl 6 Suppl):23–28. doi: 10.1136/ard.32.suppl.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dunscombe P. B., Bhattacharyya A. K., Dale R. G. The assessment of the body distribution of yttrium-90 ferric hydroxide during radiation synovectomy. Br J Radiol. 1976 Apr;49(580):372–373. doi: 10.1259/0007-1285-49-580-372. [DOI] [PubMed] [Google Scholar]
  6. Dunscombe P. B., Ramsey N. W. Radioactivity studies on 2 synovial specimens after radiation synovectomy with yttrium-90 silicate. Ann Rheum Dis. 1980 Feb;39(1):87–89. doi: 10.1136/ard.39.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Green F. A., Hays M. T. The pertechnetate joint scan. II. Clinical correlations. Ann Rheum Dis. 1972 Jul;31(4):278–281. doi: 10.1136/ard.31.4.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gumpel J. M., Beer J. C., Crawley J. C., Farran H. E. Yttrium 90 in persistent synovitis of the knee - a single centre comparison. The retention and extra-articular spread of four 90-U radiocolloids. Br J Radiol. 1975 May;48(569):377–381. doi: 10.1259/0007-1285-48-569-377. [DOI] [PubMed] [Google Scholar]
  9. Gumpel J. M. Radioactive colloids in the treatment of arthritis. Review of published and personal results. Criteria for selection of patients. Ann Rheum Dis. 1973 Dec;32 (Suppl 6)(Suppl 6 Suppl):29–33. doi: 10.1136/ard.32.suppl.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gumpel J. M., Williams E. D., Glass H. I. Use of yttrium 90 in persistent synovitis of the knee. I. Retention in the knee and spread in the body after injection. Ann Rheum Dis. 1973 May;32(3):223–227. doi: 10.1136/ard.32.3.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Huskisson E. C., Scott J., Balme H. W. Objective measurement of rheumatoid arthritis using technetium index. Ann Rheum Dis. 1976 Feb;35(1):81–82. doi: 10.1136/ard.35.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McCarty D. J., Polcyn R. E., Collins P. A., Gottschalk A. 99m-technetium scintiphotography in arthritis. I. Technic and interpretation. Arthritis Rheum. 1970 Jan-Feb;13(1):11–20. doi: 10.1002/art.1780130102. [DOI] [PubMed] [Google Scholar]
  13. Oka M., Rekonen A., Ruotsi A., Kuikka J. Measurement of systemic inflammatory activity in rheumatoid arthritis by the 99mTc method. Scand J Rheumatol. 1973;2(3):101–107. doi: 10.3109/03009747309098826. [DOI] [PubMed] [Google Scholar]
  14. Prichard H. L., Bridgman J. F., Bleehen N. M. An investigation of radioactive yttrium (90Y) for the treatment of chronic knee effusions. Br J Radiol. 1970 Jul;43(511):466–470. doi: 10.1259/0007-1285-43-511-466. [DOI] [PubMed] [Google Scholar]
  15. Roberts S. D., Gillespie P. J. Effect of immobilization on retention of 90Y. Ann Rheum Dis. 1973 Dec;32 (Suppl 6)(Suppl 6 Suppl):46–47. doi: 10.1136/ard.32.suppl.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stevenson A. C., Bedford J., Dolphin G. W., Purrott R. J., Lloyd D. C., Hill A. G., Hill H. F., Gumpel J. M., Williams D., Scott J. T. Cytogenetic and scanning study of patients receiving intra-articular injections of gold-198 and yttrium-90. Ann Rheum Dis. 1973 Mar;32(2):112–123. doi: 10.1136/ard.32.2.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williams E. D., Caughey D. E., Hurley P. J., John M. B. Distribution of yttrium 90 ferric hydroxide colloid and gold 198 colloid after injection into knee. Ann Rheum Dis. 1976 Dec;35(6):516–520. doi: 10.1136/ard.35.6.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Winfield J., Gumpel J. M. An evaluation of repeat intra-articular injections of yttrium-90 colloids in persistent synovitis of the knee. Ann Rheum Dis. 1979 Apr;38(2):145–147. doi: 10.1136/ard.38.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. de la Chapelle A., Rekonen A., Oka M., Ruotsi A. Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose. Ann Rheum Dis. 1972 Nov;31(6):508–512. doi: 10.1136/ard.31.6.508. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES