Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Dec;42(6):655–658. doi: 10.1136/ard.42.6.655

C-reactive protein and serological indices of disease activity in systemic lupus erythematosus.

J V Bertouch, P J Roberts-Thompson, P H Feng, J Bradley
PMCID: PMC1001323  PMID: 6606401

Abstract

The concentration of C-reactive protein (CRP) in sera from 70 patients with systemic lupus erythematosus (SLE) showed no correlation with commonly accepted laboratory indices of disease activity. Most patients had detectable serum CRP, but in some patients CRP was not found despite repeated testing. This absence of a CRP response did not appear to be related to medication. In some patients high levels of CRP were seen in the absence of infection. Measurement of serum CRP in SLE is unlikely to be useful in the laboratory diagnosis of disease activity.

Full text

PDF
657

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amos R. S., Constable T. J., Crockson R. A., Crockson A. P., McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. doi: 10.1136/bmj.1.6055.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Becker G. J., Waldburger M., Hughes G. R., Pepys M. B. Value of serum C-reactive protein measurement in the investigation of fever in systemic lupus erythematosus. Ann Rheum Dis. 1980 Feb;39(1):50–52. doi: 10.1136/ard.39.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bravo M. G., Alarcon-Segovia D. C-reactive protein in the differential diagnosis between infection and disease reactivation in SLE. J Rheumatol. 1981 Mar-Apr;8(2):291–294. [PubMed] [Google Scholar]
  4. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. De Beer F. C., Mallya R. K., Fagan E. A., Lanham J. G., Hughes G. R., Pepys M. B. Serum amyloid-A protein concentration in inflammatory diseases and its relationship to the incidence of reactive systemic amyloidosis. Lancet. 1982 Jul 31;2(8292):231–234. doi: 10.1016/s0140-6736(82)90321-x. [DOI] [PubMed] [Google Scholar]
  6. Deyo R. A., Pope R. M., Persellin R. H. Interference by rheumatoid factor with the detection of C-reactive protein by the latex agglutination method. J Rheumatol. 1980 May-Jun;7(3):279–287. [PubMed] [Google Scholar]
  7. HEDLUND P. Clinical and experimental studies on C-reactive protein (acute phase protein). Acta Med Scand Suppl. 1961;361:1–71. [PubMed] [Google Scholar]
  8. HILL A. G. S. C-reactive protein in the chronic rheumatic diseases. Lancet. 1951 Nov 3;2(6688):807–811. doi: 10.1016/s0140-6736(51)91595-4. [DOI] [PubMed] [Google Scholar]
  9. Honig S., Gorevic P., Weissmann G. C-reactive protein in systemic lupus erythematosus. Arthritis Rheum. 1977 Jun;20(5):1065–1070. doi: 10.1002/art.1780200505. [DOI] [PubMed] [Google Scholar]
  10. Mallya R. K., Vergani D., Tee D. E., Bevis L., de Beer F. C., Berry H., Hamilton E. D., Mace B. E., Pepys M. B. Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity. Clin Exp Immunol. 1982 Jun;48(3):747–753. [PMC free article] [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. McConkey B., Crockson R. A., Crockson A. P. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. Q J Med. 1972 Apr;41(162):115–125. [PubMed] [Google Scholar]
  13. Morrow W. J., Isenberg D. A., Parry H. F., Snaith M. L. C-reactive protein in sera from patients with systemic lupus erythematosus. J Rheumatol. 1981 Jul-Aug;8(4):599–604. [PubMed] [Google Scholar]
  14. Nydegger U. E., Lambert P. H., Gerber H., Miescher P. A. Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q. J Clin Invest. 1974 Aug;54(2):297–309. doi: 10.1172/JCI107765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Parish W. E. Studies on vasculitis. VII. C-reactive protein as a substance perpetuating chronic vasculitis. Occurrence in lesions and concentrations in sera. Clin Allergy. 1976 Nov;6(6):543–550. doi: 10.1111/j.1365-2222.1976.tb01939.x. [DOI] [PubMed] [Google Scholar]
  16. Pepys M. B. C-reactive protein fifty years on. Lancet. 1981 Mar 21;1(8221):653–657. doi: 10.1016/s0140-6736(81)91565-8. [DOI] [PubMed] [Google Scholar]
  17. Pereira Da Silva J. A., Elkon K. B., Hughes G. R., Dyck R. F., Pepys M. B. C-reactive protein levels in systemic lupus erythematosus: a classification criterion? Arthritis Rheum. 1980 Jun;23(6):770–771. doi: 10.1002/art.1780230609. [DOI] [PubMed] [Google Scholar]
  18. Pincus T. Immunochemical conditions affecting the measurement of DNA antibodies using ammonium sulfate precipitation. Arthritis Rheum. 1971 Sep-Oct;14(5):623–630. doi: 10.1002/art.1780140509. [DOI] [PubMed] [Google Scholar]
  19. Zein N., Ganuza C., Kushner I. Significance of serum C-reactive protein elevation in patients with systemic lupus erythematosus. Arthritis Rheum. 1979 Jan;22(1):7–12. doi: 10.1002/art.1780220102. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES