Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Dec;42(6):680–683. doi: 10.1136/ard.42.6.680

1 Alpha 2 alpha 3 alpha collagen is arthritogenic.

K Morgan, H B Evans, S A Firth, M N Smith, S Ayad, J B Weiss, P J Lennox Holt
PMCID: PMC1001329  PMID: 6651372

Abstract

Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms per rat) was immunogenic and arthritogenic in both strains (64% arthritic in Alderley Park strain, 57% arthritic in Sprague-Dawley strain). The inflammatory polyarthritis induced by 1 alpha 2 alpha 3 alpha collagen was similar to that produced by native type II collagen in clinical appearance, time of onset, and histology. Antibodies raised to native bovine type II collagen cross-reacted with native 1 alpha 2 alpha 3 alpha collagen and vice versa. Thus the minor collagen component of cartilage, the 1 alpha 2 alpha 3 alpha collagen, as well as the major collagen component, type II collagen, are immunogenic and arthritogenic in the rat, with strain differences.

Full text

PDF
680

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ayad S., Abedin M. Z., Grundy S. M., Weiss J. B. Isolation and characterisation of an unusual collagen from hyaline cartilage and intervertebral disc. FEBS Lett. 1981 Jan 26;123(2):195–199. doi: 10.1016/0014-5793(81)80286-4. [DOI] [PubMed] [Google Scholar]
  2. Ayad S., Abedin M. Z., Weiss J. B., Grundy S. M. Characterisation of another short-chain disulphide-bonded collagen from cartilage, vitreous and intervertebral disc. FEBS Lett. 1982 Mar 22;139(2):300–304. doi: 10.1016/0014-5793(82)80875-2. [DOI] [PubMed] [Google Scholar]
  3. BITTER T., MUIR H. M. A modified uronic acid carbazole reaction. Anal Biochem. 1962 Oct;4:330–334. doi: 10.1016/0003-2697(62)90095-7. [DOI] [PubMed] [Google Scholar]
  4. Burgeson R. E., Hollister D. W. Collagen heterogeneity in human cartilage: identification of several new collagen chains. Biochem Biophys Res Commun. 1979 Apr 27;87(4):1124–1131. doi: 10.1016/s0006-291x(79)80024-8. [DOI] [PubMed] [Google Scholar]
  5. Clague R. B., Brown R. A., Weiss J. B., Holt P. J. Solid-phase radioimmunoassay for the detection of antibodies to collagen. J Immunol Methods. 1979 May 10;27(1):31–41. doi: 10.1016/0022-1759(79)90236-9. [DOI] [PubMed] [Google Scholar]
  6. Courtenay J. S., Dallman M. J., Dayan A. D., Martin A., Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980 Feb 14;283(5748):666–668. doi: 10.1038/283666a0. [DOI] [PubMed] [Google Scholar]
  7. Griffiths M. M., Eichwald E. J., Martin J. H., Smith C. B., DeWitt C. W. Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats. Arthritis Rheum. 1981 Jun;24(6):781–789. doi: 10.1002/art.1780240605. [DOI] [PubMed] [Google Scholar]
  8. Morgan K., Clague R. B., Shaw M. J., Holt P. J. Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen. Ann Rheum Dis. 1980 Jun;39(3):285–290. doi: 10.1136/ard.39.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Stuart J. M., Cremer M. A., Kang A. H., Townes A. S. Collagen-induced arthritis in rats. Evaluation of early immunologic events. Arthritis Rheum. 1979 Dec;22(12):1344–1351. doi: 10.1002/art.1780221205. [DOI] [PubMed] [Google Scholar]
  10. Trentham D. E., Townes A. S., Kang A. H. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977 Sep 1;146(3):857–868. doi: 10.1084/jem.146.3.857. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES