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. 1984 Jun;43(3):470–476. doi: 10.1136/ard.43.3.470

An immunohistological study of secondary Sjögren's syndrome.

D A Isenberg, D Rowe, A Tookman, A Hopp, M Griffiths, E Paice, J Stewart, P C Beverley
PMCID: PMC1001372  PMID: 6378107

Abstract

The labial biopsies from 13 patients with secondary Sjögren's syndrome (SS) and four disease controls were examined with a panel of monoclonal antibodies to human leucocyte antigens. Large numbers of T cells were found in most of the biopsies. In seven SS patients the T helper/inducer subset was found to be predominant. Antibody to HLA class I antigens consistently stained leucocytes, but other cell types stained more variably. Although the staining with antibody to HLA class II antigen was often weak, approximately as many cells stained with this antibody as with an antileucocyte antibody, implying that the T cells were activated. Anti-IgD revealed membrane staining of a corona of IgD-positive cells in structures resembling germinal centres. Isolated cells throughout the sections also showed strong cytoplasmic staining with anti-IgD. These results suggest a role for T-cell-dependent local antibody synthesis in the pathogenesis of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. A., Whaley K., Williamson J., Buchanan W. W. A statistical aid to the diagnosis of keratoconjunctivitis sicca. Q J Med. 1972 Apr;41(162):175–189. [PubMed] [Google Scholar]
  2. Anderson L. G., Cummings N. A., Asofsky R., Hylton M. B., Tarpley T. M., Jr, Tomasi T. B., Jr, Wolf R. O., Schall G. L., Talal N. Salivary gland immunoglobulin and rheumatoid factor synthesis in Sjögren's syndrome. Natural history and response to treatment. Am J Med. 1972 Oct;53(4):456–463. doi: 10.1016/0002-9343(72)90141-6. [DOI] [PubMed] [Google Scholar]
  3. Beverley P. C., Callard R. E. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981 Apr;11(4):329–334. doi: 10.1002/eji.1830110412. [DOI] [PubMed] [Google Scholar]
  4. Chisholm D. M., Mason D. K. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968 Sep;21(5):656–660. doi: 10.1136/jcp.21.5.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DeCoteau W. E., Katakkar S. B., Skinnider L., Hayton R. C., Somerville E. A. Sjögren's syndrome terminating as a myeloproliferative disorder. J Rheumatol. 1975 Sep;2(3):331–335. [PubMed] [Google Scholar]
  6. Dunne J. V., Carson D. A., Spiegelberg H. L., Alspaugh M. A., Vaughan J. H. IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. Ann Rheum Dis. 1979 Apr;38(2):161–165. doi: 10.1136/ard.38.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fleming K. A., McMichael A., Morton J. A., Woods J., McGee J. O. Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer. J Clin Pathol. 1981 Jul;34(7):779–784. doi: 10.1136/jcp.34.7.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fox R. I., Carstens S. A., Fong S., Robinson C. A., Howell F., Vaughan J. H. Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjögren's syndrome. Arthritis Rheum. 1982 Apr;25(4):419–426. doi: 10.1002/art.1780250410. [DOI] [PubMed] [Google Scholar]
  9. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  10. Ledbetter J. A., Evans R. L., Lipinski M., Cunningham-Rundles C., Good R. A., Herzenberg L. A. Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J Exp Med. 1981 Feb 1;153(2):310–323. doi: 10.1084/jem.153.2.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MORGAN W. S., CASTLEMAN B. A clinicopathologic study of Mikulicz's disease. Am J Pathol. 1953 May-Jun;29(3):471–503. [PMC free article] [PubMed] [Google Scholar]
  12. Manthorpe R., Frost-Larsen K., Isager H., Prause J. U. Sjögren's syndrome. A review with emphasis on immunological features. Allergy. 1981 Apr;36(3):139–153. doi: 10.1111/j.1398-9995.1981.tb01829.x. [DOI] [PubMed] [Google Scholar]
  13. Morimoto C., Reinherz E. L., Schlossman S. F., Schur P. H., Mills J. A., Steinberg A. D. Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J Clin Invest. 1980 Nov;66(5):1171–1174. doi: 10.1172/JCI109948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rowe D. J., Isenberg D. A., McDougall J., Beverley P. C. Characterization of polymyositis infiltrates using monoclonal antibodies to human leucocyte antigens. Clin Exp Immunol. 1981 Aug;45(2):290–298. [PMC free article] [PubMed] [Google Scholar]
  15. Rowe D., Isenberg D. A., Beverley P. C. Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy. Clin Exp Immunol. 1983 Nov;54(2):327–336. [PMC free article] [PubMed] [Google Scholar]
  16. Strand V., Talal N. Advances in the diagnosis and concept of Sjögren's syndrome (autoimmune exocrinopathy). Bull Rheum Dis. 1979;30(9):1046–1052. [PubMed] [Google Scholar]
  17. Talal N., Asofsky R., Lightbody P. Immunoglobulin synthesis by salivary gland lymphoid cells in Sjögren's syndrome. J Clin Invest. 1970 Jan;49(1):49–54. doi: 10.1172/JCI106221. [DOI] [PMC free article] [PubMed] [Google Scholar]

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