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. 1984 Aug;43(4):590–593. doi: 10.1136/ard.43.4.590

Absence of impaired lymphocyte transformation to Klebsiella spp. in ankylosing spondylitis.

T D Kinsella, C Lanteigne, M J Fritzler, R M Lewkonia
PMCID: PMC1001415  PMID: 6332581

Abstract

We have evaluated claims that impaired peripheral blood lymphocyte (PBL) transformation can occur with Klebsiella spp. in patients with ankylosing spondylitis (AS). PBL of four AS patients were cultured in vitro with autogenous faecal klebsiella, as were the PBL of age (+/- 3 years) and sex-matched pairs of 15-20 AS and normal controls cultured with heterogeneous AS-derived klebsiella and control bacterial isolates. Three of four AS patients responded to their own isolates, and no significant differences were found between the matched pairs in response to heterogeneous klebsiella isolates, including K21. Our studies did not show impaired PBL transformation with klebsiella in AS and therefore do not support claims of antigenic cross-reactivity between klebsiella and HLA-B27.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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