Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Apr;43(2):136–139. doi: 10.1136/ard.43.2.136

A study of lymphocytotoxins in families of patients with systemic lupus erythematosus.

R A Hazelton
PMCID: PMC1001449  PMID: 6370147

Abstract

Lymphocytotoxic antibodies are a common feature in the sera of patients with systemic lupus erythematosus. This family study, however, has not confirmed the previous findings of an increased incidence in the sera of their relatives. Adsorption studies suggest that when lymphocytotoxins occur in the sera of normal subjects and relatives of patients they have a different specificity and thus significance.

Full text

PDF
137

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bluestein H. G., Zvaifler N. J. Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976 Feb;57(2):509–516. doi: 10.1172/JCI108303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bresnihan B., Grigor R. R., Hughes G. R. Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance. J Clin Pathol Suppl (R Coll Pathol) 1979;13:112–115. doi: 10.1136/jcp.s3-13.1.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Browning J. D., Dick H. M., Sturrock R., Grennan D., Dick W. C. Cold lymphocytotoxins in connective tissue disorders. Scott Med J. 1979 Jan;24(1):5–8. doi: 10.1177/003693307902400102. [DOI] [PubMed] [Google Scholar]
  4. Cleland L. G., Bell D. A., Willans M., Saurino B. C. Familial lupus. Family studies of HLA and serologic findings. Arthritis Rheum. 1978 Mar;21(2):183–191. doi: 10.1002/art.1780210202. [DOI] [PubMed] [Google Scholar]
  5. DeHoratius R. J., Messner R. P. Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest. 1975 Jun;55(6):1254–1258. doi: 10.1172/JCI108044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Folomeeva O., Nassonova V. A., Alekberova A. S., Talal N., Williams R. C., Jr Comparative studies of antilymphocyte, antipolynucleotide, and antiviral antibodies among families of patients with systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):23–27. doi: 10.1002/art.1780210105. [DOI] [PubMed] [Google Scholar]
  7. Goldberg L. S., Bresnihan B., Hughes G. R. Lymphocytotoxic antibodies in systemic lupus erythematosus: evidence for reactivity with i antigen. Clin Exp Immunol. 1978 Mar;31(3):443–447. [PMC free article] [PubMed] [Google Scholar]
  8. Kasukawa R., Kano K., Bloom M. L., Milgrom F. Heterophile antibodies in pathologic human sera resembling antibodies stimulated by foreign species sera. Clin Exp Immunol. 1976 Jul;25(1):122–132. [PMC free article] [PubMed] [Google Scholar]
  9. Malavé I., Papa R., Layrisse Z. Lymphocytotoxic antibodies in SLE patients and their relatives. Arthritis Rheum. 1976 Jul-Aug;19(4):700–704. doi: 10.1002/1529-0131(197607/08)19:4<700::aid-art1780190407>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  10. Mendius J. R., DeHoratius R. J., Messner R. P., Williams R. C. Family distribution of lymphocytotoxins in Hodgkin's disease. Ann Intern Med. 1976 Feb;84(2):151–156. doi: 10.7326/0003-4819-84-2-151. [DOI] [PubMed] [Google Scholar]
  11. Messner R. P., De Horatius R. J. Epidemiology of anti-lymphocyte antibodies in systemic lupus erythematosus. Arthritis Rheum. 1978 Jun;21(5 Suppl):S167–S170. [PubMed] [Google Scholar]
  12. Messner R. P., De Horatius R., Ferrone S. Lymphocytotoxic antibodies in systemic lupus erythematosus patients and their relatives: reactivity with the HLA antigenic molecular complex. Arthritis Rheum. 1980 Mar;23(3):265–272. doi: 10.1002/art.1780230301. [DOI] [PubMed] [Google Scholar]
  13. Milgrom F., Kano K., Fjelde A., Bloom M. L. Heterophile antigens and antibodies in transplantation and tumors. Transplant Proc. 1975 Jun;7(2):201–207. [PubMed] [Google Scholar]
  14. Naito S., Mickey M. R., Hirata A., Terasaki P. I. Autolymphocytotoxins following immunization by pregnancy, transplantation, and disease. Tissue Antigens. 1971;1(5):219–228. doi: 10.1111/j.1399-0039.1971.tb00099.x. [DOI] [PubMed] [Google Scholar]
  15. Ozturk G., Terasaki P. I. Non-HLA lymphocyte cytotoxins in various diseases. Tissue Antigens. 1979 Jul;14(1):52–58. doi: 10.1111/j.1399-0039.1979.tb00821.x. [DOI] [PubMed] [Google Scholar]
  16. Schocket A. L., Weiner H. L. Lymphocytotoxic antibodies in family members of patients with multiple sclerosis. Lancet. 1978 Mar 18;1(8064):571–573. doi: 10.1016/s0140-6736(78)91023-1. [DOI] [PubMed] [Google Scholar]
  17. Shumak K. H., Rachkewich R. A., Crookston M. C., Crookston J. H. Antigens of the Ii system on lymphocytes. Nat New Biol. 1971 Jun 2;231(22):148–149. doi: 10.1038/newbio231148a0. [DOI] [PubMed] [Google Scholar]
  18. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  19. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  20. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES