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. 1984 Apr;43(2):279–284. doi: 10.1136/ard.43.2.279

Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27.

C T Pease, J N Fordham, H L Currey
PMCID: PMC1001483  PMID: 6608924

Abstract

Polymorphonuclear leucocyte (PMN) function was studied in 29 subjects with ankylosing spondylitis (AS). Of these, 20 were HLA B27+ve and 9 B27-ve. There were 30 controls and, of these, 15 were B27+ve. Random and directed cell migration was measured by 2 techniques: migration through a micropore filter and migration under an agar film. The chemo-attractant was either case in-activated serum or zymosan-activated serum. By both techniques directed motility was increased in subjects with B27 or with AS when compared to the B27-ve controls. This suggests that the disease AS and the possession of B27 are both associated with increased PMN motility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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