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. 1984 Apr;43(2):313–319. doi: 10.1136/ard.43.2.313

Stimulation of glycosaminoglycan production and lysosomal activity of human synovial cells in culture by low environmental pH.

B J Clarris, J R Fraser, K D Muirden, L P Malcolm, M W Holmes, K Rogers
PMCID: PMC1001490  PMID: 6712304

Abstract

Glycosaminoglycan production, acid hydrolase activity, proliferation, and morphology were examined in human synovial cells subjected to low environmental pH. The amount and the molecular size of newly synthesised glycosaminoglycan (GAG) were increased without significant change in the rate of cell proliferation. Lowered pH produced an increase in the size of cytoplasmic organelles. Some of these possessed ultrastructural features of lysosomes, but others were clearly nonlysosomal and were of uncertain identity. Intracellular activity of the lysosomal acid hydrolase N-acetyl-beta-glucosaminidase (NAG) was not altered by low pH, but a marked increase occurred in extracellular NAG activity, indicating enhanced release.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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