Abstract
Etretinate (Tigason) and ibuprofen have been compared in a double-blind controlled trial in psoriatic arthritis to see if we could confirm a specific action for this vitamin A derivative suggested from earlier uncontrolled studies. Eleven out of 20 patients completed 24 weeks of therapy with etretinate (up to 0.5 mg/kg/day) whereas only 1/20 patients completed 24 weeks of therapy with ibuprofen alone. Etretinate improved skin lesions, and this may have encouraged patients to persist with it. Improvement of statistical significance was seen for articular index in both groups. In addition significant improvement in ESR, haemoglobin, C-reactive protein, and histidine occurred in the etretinate group. The main side effects of etretinate (which may preclude its use at a higher dose in this condition) included cracked and dried lips and sore mouth.
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Selected References
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- Bollag W. Vitamin A and retinoids: from nutrition to pharmacotherapy in dermatology and oncology. Lancet. 1983 Apr 16;1(8329):860–863. doi: 10.1016/s0140-6736(83)91394-6. [DOI] [PubMed] [Google Scholar]
- Mayer H., Bollag W., Hänni R., Rüegg R. Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia. 1978 Sep 15;34(9):1105–1119. doi: 10.1007/BF01922901. [DOI] [PubMed] [Google Scholar]
- Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
- Rosenthal M. Retinoid in der Behandlung von Psoriasis-Arthritis: Eine Pilotstudie. Schweiz Med Wochenschr. 1979 Dec 15;109(48):1912–1914. [PubMed] [Google Scholar]