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. 1986 Jan;45(1):67–74. doi: 10.1136/ard.45.1.67

Studies on the chronic phase of adjuvant arthritis: effect of SR 41319, a new diphosphonate.

A Barbier, J C Breliére, B Remandet, R Roncucci
PMCID: PMC1001817  PMID: 3754110

Abstract

We studied the course of adjuvant arthritis in rats by measuring clinical, biochemical, and histological parameters on day 36 after induction (representing the secondary reaction) and on day 171, which is at the stage of permanent deformity. The effect of SR 41319, a new diphosphonate, was evaluated on days 36 and 171, after three weeks of treatment (days 14-35 inclusive). In the absence of treatment all the measured parameters were markedly abnormal on day 36, indicating the presence of lesions that were still evolving. On day 171 clinical parameters and the lesion histological index remained the same, whereas the biochemical parameters and disease activity histological index had returned to normal, indicating that the lesions at this stage although severe were not inflammatory and consequently not progressing. SR 41319 treatment reduced the severity and progression of the disease both on day 36 and on day 171. We conclude that SR 41319 may be a potentially useful drug for the treatment of rheumatoid arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bijvoet O. L., Frijlink W. B., Jie K., van der Linden H., Meijer C. J., Mulder H., van Paassen H. C., Reitsma P. H., te Velde J., de Vries E. APD in Paget's disease of bone. Role of the mononuclear phagocyte system? Arthritis Rheum. 1980 Oct;23(10):1193–1204. doi: 10.1002/art.1780231018. [DOI] [PubMed] [Google Scholar]
  2. Buttler M., Giannina T., Cargill D. I., Popick F., Steinetz B. G. Abnormal sulfhydryl-disulfide interchange in serum of rats with adjuvant arthritis: correction by anti-inflammatory agents. Proc Soc Exp Biol Med. 1969 Nov;132(2):484–488. doi: 10.3181/00379727-132-34242. [DOI] [PubMed] [Google Scholar]
  3. Dray F., Charbonnel B., Maclouf J. Radioimmunoassay of prostaglandins Falpha, E1 and E2 in human plasma. Eur J Clin Invest. 1975 Jul 29;5(4):311–318. doi: 10.1111/j.1365-2362.1975.tb00459.x. [DOI] [PubMed] [Google Scholar]
  4. Fast D. K., Felix R., Dowse C., Neuman W. F., Fleisch H. The effects of diphosphonates on the growth and glycolysis of connective-tissue cells in culture. Biochem J. 1978 Apr 15;172(1):97–107. doi: 10.1042/bj1720097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Flora L. Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis. Arthritis Rheum. 1979 Apr;22(4):340–346. doi: 10.1002/art.1780220405. [DOI] [PubMed] [Google Scholar]
  6. Francis M. D., Flora L., King W. R. The effects of disodium ethane-1-hydroxy-1, 1-diphosphonate on adjuvant induced arthritis in rats. Calcif Tissue Res. 1972;9(2):109–121. doi: 10.1007/BF02061949. [DOI] [PubMed] [Google Scholar]
  7. Hart F. D., Huskisson E. C. Non-steroidal anti-inflammatory drugs. Current status and rational therapeutic use. Drugs. 1984 Mar;27(3):232–255. doi: 10.2165/00003495-198427030-00004. [DOI] [PubMed] [Google Scholar]
  8. Labat M. L., Florentin I., Davigny M., Moricard Y., Milhaud G. Dichloromethylene diphosphonate (Cl2MDP) reduces natural killer (NK) cell activity in mice. Metab Bone Dis Relat Res. 1984;5(6):281–287. doi: 10.1016/0221-8747(84)90015-8. [DOI] [PubMed] [Google Scholar]
  9. Milhaud G., Labat M. L., Moricard Y. (Dichloromethylene)diphosphonate-induced impairment of T-lymphocyte function. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4469–4473. doi: 10.1073/pnas.80.14.4469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nouri A. M., Panayi G. S., Goodman S. M. Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol. 1984 Feb;55(2):295–302. [PMC free article] [PubMed] [Google Scholar]
  11. Owen R. T. Adjuvant induced polyarthritis - an overview. Methods Find Exp Clin Pharmacol. 1980 Aug;2(4):199–204. [PubMed] [Google Scholar]
  12. Tan P., Shore A., Leary P., Keystone E. C. Interleukin abnormalities in recently active rheumatoid arthritis. J Rheumatol. 1984 Oct;11(5):593–596. [PubMed] [Google Scholar]
  13. Vaes G., Jacques P. Studies on bone enzymes. The assay of acid hydrolases and other enzymes in bone tissue. Biochem J. 1965 Nov;97(2):380–388. doi: 10.1042/bj0970380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. de Vries E., van der Weij J. P., van der Veen C. J., van Paassen H. C., Jager M. J., Sleeboom H. P., Bijvoet O. L., Cats A. In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation. Immunology. 1982 Sep;47(1):157–163. [PMC free article] [PubMed] [Google Scholar]

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