Abstract
Nineteen patients with hip radiographs typical of 'analgesic hip' (rapidly destructive, atrophic arthropathy involving both femoral and acetabular components) have been studied. Women predominated (14:5), and all were elderly (mean age 74 years, range 64-83 years). Destructive hip disease was unilateral in all but one case. The mean interval from symptom onset to typical x ray appearance was short (one year, range three to 24 months), and persistent pain unresponsive to drug therapy was characteristic. Screening showed no metabolic or neurological disease. Contrary to previous reports, non-steroidal anti-inflammatory drugs could not be incriminated in development of the disease. Clinical and radiographic similarity to apatite associated destructive arthritis of other large joints was striking, and occurrence of the latter, uncommon condition in five patients (five shoulders, two knees) suggests that both descriptions represent a common articular response at different joint sites.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arora J. S., Maudsley R. H. Indomethacin arthropathy of hips. Proc R Soc Med. 1968 Jul;61(7):669–669. [PMC free article] [PubMed] [Google Scholar]
- Hauge M. F. Hofteleddsartrose - indometacin. Tidsskr Nor Laegeforen. 1975 Oct 10;95(28):1594-6, 1603. [PubMed] [Google Scholar]
- Huusko P. J., Nieminen L. H., Nieminen L. S. The effect of indomethacin on tooth extraction wound healing in rats. Experientia. 1975 Sep 15;31(9):1056–1058. doi: 10.1007/BF02326957. [DOI] [PubMed] [Google Scholar]
- Richards A. J., Hamilton E. B. Destructive arthropathy in chondrocalcinosis articularis. Ann Rheum Dis. 1974 May;33(3):196–203. doi: 10.1136/ard.33.3.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solomon L. Drug-induced arthropathy and necrosis of the femoral head. J Bone Joint Surg Br. 1973 May;55(2):246–261. [PubMed] [Google Scholar]
- Storey G. O. Bone necrosis in joint disease. Proc R Soc Med. 1968 Oct;61(10):961–969. [PMC free article] [PubMed] [Google Scholar]
- Sudmann E. Effect of indomethacin on bone remodelling in rabbit ear chambers. Acta Orthop Scand Suppl. 1975;160:91–115. [PubMed] [Google Scholar]
- Watson M. The suppressing effect of indomethacin on articular cartilage. Rheumatol Rehabil. 1976 Feb;15(1):26–30. doi: 10.1093/rheumatology/15.1.26. [DOI] [PubMed] [Google Scholar]