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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1986 Aug;45(8):684–690. doi: 10.1136/ard.45.8.684

Rheumatoid factor tests in the diagnosis and prediction of rheumatoid arthritis.

D J Walker, J D Pound, I D Griffiths, R J Powell
PMCID: PMC1001968  PMID: 3488715

Abstract

Four assays of rheumatoid factor (RF) have been measured on serum from 213 individuals from 13 families containing at least two sufferers from classical or definite rheumatoid arthritis (RA). Families were not uniformly RF positive or negative, and there was no evidence that non-RA RF positivity was inherited. Four individuals developed definite RA over a two year period, showing that the family members were at increased risk of RA. IgG RF and latex RF assays predicted the RA in the four cases. An association of RF positivity in RA with DR4 was observed, but this may be related to disease severity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aho K., Palosuo T., Raunio V., Puska P., Aromaa A., Salonen J. T. When does rheumatoid disease start? Arthritis Rheum. 1985 May;28(5):485–489. doi: 10.1002/art.1780280503. [DOI] [PubMed] [Google Scholar]
  2. Allen C., Elson C. J., Scott D. G., Bacon P. A., Bucknall R. C. IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinical features and other parameters. Ann Rheum Dis. 1981 Apr;40(2):127–131. doi: 10.1136/ard.40.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bardin T., Legrand L., Naveau B., Marcelli-Barge A., Debeyre N., Lathrop G. M., Poirier J. C., Schmid M., Ryckewaert A., Dryll A. HLA antigens and seronegative rheumatoid arthritis. Ann Rheum Dis. 1985 Jan;44(1):50–53. doi: 10.1136/ard.44.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bradlow A., Mowat A. G. Comparison of reconstructive orthopaedic surgery in patients with seropositive and seronegative rheumatoid arthritis. Br J Rheumatol. 1985 May;24(2):179–186. doi: 10.1093/rheumatology/24.2.179. [DOI] [PubMed] [Google Scholar]
  5. Burns T. M., Calin A. The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rheumatoid arthritis': a controlled study. Ann Rheum Dis. 1983 Dec;42(6):605–612. doi: 10.1136/ard.42.6.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Carson D. A., Bayer A. S., Eisenberg R. A., Lawrance S., Theofilopoulos A. IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol. 1978 Jan;31(1):100–103. [PMC free article] [PubMed] [Google Scholar]
  7. Dobloug J. H., Førre O., Kåss E., Thorsby E. HLA antigens and rheumatoid arthritis. Association between HLA-DRw4 positivity and IgM rheumatoid factor production. Arthritis Rheum. 1980 Mar;23(3):309–313. doi: 10.1002/art.1780230307. [DOI] [PubMed] [Google Scholar]
  8. Engleman E. G., Sponzilli E. E., Batey M. E., Ramcharan S., McDevitt H. O. Mixed lymphocyte reaction in healthy women with rheumatoid factor. Lack of association with HLA-Dw4. Arthritis Rheum. 1978 Jul-Aug;21(6):690–693. doi: 10.1002/art.1780210613. [DOI] [PubMed] [Google Scholar]
  9. Gran J. T., Husby G., Thorsby E. The prevalence of HLA-DR4 and HLA-DR3 in healthy persons with rheumatoid factor. Scand J Rheumatol. 1985;14(1):79–82. doi: 10.3109/03009748509102024. [DOI] [PubMed] [Google Scholar]
  10. LAWRENCE J. S., BALL J. Genetic studies on rheumatoid arthritis. Ann Rheum Dis. 1958 Jun;17(2):160–168. doi: 10.1136/ard.17.2.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Panayi G. S., Wooley P. H., Batchelor J. R. HLA-DRw4 and rheumatoid arthritis. Lancet. 1979 Mar 31;1(8118):730–730. doi: 10.1016/s0140-6736(79)91186-3. [DOI] [PubMed] [Google Scholar]
  12. Powell R. J., Leyland A. M., Pound J. D., Bossingham D. H. An improved assay for IgG rheumatoid factor: its value in the diagnosis of rheumatoid arthritis. J Rheumatol. 1985 Jun;12(3):427–431. [PubMed] [Google Scholar]
  13. Queirós M. V., Sancho M. R., Caetano J. M. HLA-DR4 antigen and IgM rheumatoid factors. J Rheumatol. 1982 May-Jun;9(3):370–373. [PubMed] [Google Scholar]
  14. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  15. Roitt I. M., Corbett M., Festenstein H., Jaraquemada D., Papasteriadis C., Hay F. C., Nineham L. J. HLA-DRW4 and prognosis in rheumatoid arthritis. Lancet. 1978 May 6;1(8071):990–990. doi: 10.1016/s0140-6736(78)90280-5. [DOI] [PubMed] [Google Scholar]
  16. Rudge S. R., Pound J. D., Bossingham D. H., Powell R. J. Class specific rheumatoid factors in rheumatoid arthritis: response to chrysotherapy and relationship to disease activity. J Rheumatol. 1985 Jun;12(3):432–436. [PubMed] [Google Scholar]
  17. Walker D. J., Griffiths M., Dewar P., Coates E., Dick W. C., Thompson M., Griffiths I. D. Association of MHC antigens with susceptibility to and severity of rheumatoid arthritis in multicase families. Ann Rheum Dis. 1985 Aug;44(8):519–525. doi: 10.1136/ard.44.8.519. [DOI] [PMC free article] [PubMed] [Google Scholar]

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