Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1986 Nov;45(11):925–931. doi: 10.1136/ard.45.11.925

Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. IV. Increased numbers and activation of Facb-R+ cells after immunisation of healthy individuals.

N J Goulding, L J Eales, N D Hall
PMCID: PMC1002021  PMID: 3098196

Abstract

Mononuclear cells expressing Fc gamma receptors that form Facb rosettes are increased in the peripheral blood of patients with rheumatoid arthritis compared with controls. Healthy individuals with a positive skin response to tuberculin showed a marked increase in numbers of circulating Facb-R+ cells three days after challenge, returning to baseline after seven days. No response was observed in subjects showing a negative skin test. A similar increase in Facb-R+ cell numbers was measured after intramuscular injection of another specific antigen, tetanus toxoid. In addition to this enhancement of Facb-R+ cell numbers, evidence has been obtained that these cells are in an activated state postimmunisation as judged by acquisition of low density and increased expression of class II MHC antigens. Apparently identical changes in Facb-R+ cell numbers and activation may be induced in vitro either by culturing sensitised mononuclear cells with specific antigen for three days or by an overnight incubation of normal cells with gamma-interferon (gamma-IFN). By analogy, therefore, the increased numbers of Facb-R+ cells in patients with rheumatoid arthritis are probably induced by gamma-interferon generated as part of an antigen driven immune response. In this context it is interesting that patients with Felty's syndrome, in whom neutropenia increases susceptibility to infections leading to the possibility of further stimulation of the immune system by micro-organisms, have particularly high levels of circulating Facb-R+ cells.

Full text

PDF
925

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biondi A., Roach J. A., Schlossman S. F., Todd R. F., 3rd Phenotypic characterization of human T lymphocyte populations producing macrophage-activating factor (MAF) lymphokines. J Immunol. 1984 Jul;133(1):281–285. [PubMed] [Google Scholar]
  2. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
  3. Carter S. D., Bourne J. T., Elson C. J., Hutton C. W., Czudek R., Dieppe P. A. Mononuclear phagocytes in rheumatoid arthritis: Fc-receptor expression by peripheral blood monocytes. Ann Rheum Dis. 1984 Jun;43(3):424–429. doi: 10.1136/ard.43.3.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eales L. J., Goulding N. J., Hall N. D., Winrow V. R., Hunneyball I. M. Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. III. Immunoregulatory function associated with Facb rosette-forming cells. Ann Rheum Dis. 1985 Jan;44(1):8–12. doi: 10.1136/ard.44.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Eales L. J., Hall N. D., Hunneyball I. M. Facb rosette-forming cells in mice: studies on their functional significance. Immunology. 1984 May;52(1):17–24. [PMC free article] [PubMed] [Google Scholar]
  6. Evans R. L., Faldetta T. J., Humphreys R. E., Pratt D. M., Yunis E. J., Schlossman S. F. Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J Exp Med. 1978 Nov 1;148(5):1440–1445. doi: 10.1084/jem.148.5.1440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hall N. D., Winrow V. R., Bacon P. A. Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. I. An increased subpopulation of cells in rheumatoid arthritis detected with Facb rosettes. Ann Rheum Dis. 1980 Dec;39(6):554–558. doi: 10.1136/ard.39.6.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hooks J. J., Moutsopoulos H. M., Geis S. A., Stahl N. I., Decker J. L., Notkins A. L. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med. 1979 Jul 5;301(1):5–8. doi: 10.1056/NEJM197907053010102. [DOI] [PubMed] [Google Scholar]
  9. McKeown M. J., Hall N. D., Corvalan J. R. Defective monocyte accessory function due to surface sulphydryl (SH) oxidation in rheumatoid arthritis. Clin Exp Immunol. 1984 Jun;56(3):607–613. [PMC free article] [PubMed] [Google Scholar]
  10. Perussia B., Dayton E. T., Lazarus R., Fanning V., Trinchieri G. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J Exp Med. 1983 Oct 1;158(4):1092–1113. doi: 10.1084/jem.158.4.1092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sharpin R. K., Simmons M. H., Wilson J. D. TG cells in peripheral blood lymphocytes from patients with rheumatoid arthritis. Clin Exp Immunol. 1981 Sep;45(3):538–543. [PMC free article] [PubMed] [Google Scholar]
  12. Steeg P. S., Moore R. N., Johnson H. M., Oppenheim J. J. Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity. J Exp Med. 1982 Dec 1;156(6):1780–1793. doi: 10.1084/jem.156.6.1780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Steinman R. M., Machtinger B. G., Fried J., Cohn Z. A. Mouse spleen lymphoblasts generated in vitro. Recovery in high yield and purity after floatation in dense bovine plasma albumin solutions. J Exp Med. 1978 Feb 1;147(2):279–296. doi: 10.1084/jem.147.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Torok-Storb B., Nepom G. T., Nepom B. S., Hansen J. A. HLA-DR antigens on lymphoid cells differ from those on myeloid cells. Nature. 1983 Oct 6;305(5934):541–543. doi: 10.1038/305541a0. [DOI] [PubMed] [Google Scholar]
  15. Unanue E. R., Beller D. I., Lu C. Y., Allen P. M. Antigen presentation: comments on its regulation and mechanism. J Immunol. 1984 Jan;132(1):1–5. [PubMed] [Google Scholar]
  16. Winrow V. R., Eales L. J., Hall N. D., Goulding N. J., Hunneyball I. M. Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. II. Phenotypic characterisation of mononuclear cells forming Facb rosettes in RA. Ann Rheum Dis. 1985 Jan;44(1):2–7. doi: 10.1136/ard.44.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wooley P. H., Panayi G. S. Studies of lymphocytes in rheumatoid arthritis. I. Uptake of 125I-heat aggregated human IgG by Fc-receptor bearing lymphocytes. Ann Rheum Dis. 1978 Aug;37(4):343–346. doi: 10.1136/ard.37.4.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yu D. T., Winchester R. J., Fu S. M., Gibofsky A., Ko H. S., Kunkel H. G. Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization. J Exp Med. 1980 Jan 1;151(1):91–100. doi: 10.1084/jem.151.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES