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. 1987 Mar;46(3):184–188. doi: 10.1136/ard.46.3.184

Psoriatic arthritis: clinical subgroups and histocompatibility antigens.

N J McHugh, M R Laurent, B L Treadwell, J M Tweed, J Dagger
PMCID: PMC1002097  PMID: 3579382

Abstract

Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong R. D., Panayi G. S., Welsh K. I. Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondylitis. Ann Rheum Dis. 1983 Apr;42(2):142–146. doi: 10.1136/ard.42.2.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eastmond C. J., Woodrow J. C. The HLA system and the arthropathies associated with psoriasis. Ann Rheum Dis. 1977 Apr;36(2):112–120. doi: 10.1136/ard.36.2.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gerber L. H., Murray C. L., Perlman S. G., Barth W. F., Decker J. L., Nigra T. A., Mann D. L. Human lymphocyte antigens characterizing psoriatic arthritis and its subtypes. J Rheumatol. 1982 Sep-Oct;9(5):703–707. [PubMed] [Google Scholar]
  4. Green L., Meyers O. L., Gordon W., Briggs B. Arthritis in psoriasis. Ann Rheum Dis. 1981 Aug;40(4):366–369. doi: 10.1136/ard.40.4.366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KELLGREN J. H. Diagnostic criteria for population studies. Bull Rheum Dis. 1962 Nov;13:291–292. [PubMed] [Google Scholar]
  6. Krain L. S., Newcomer V. D., Terasaki P. I. HL-A antigen in psoriasis. N Engl J Med. 1973 Jun 7;288(23):1245–1245. doi: 10.1056/nejm197306072882321. [DOI] [PubMed] [Google Scholar]
  7. McKendry R. J., Sengar D. P., DesGroseilliers J. P., Dunne J. V. Frequency of HLA antigens in patients with psoriasis or psoriatic arthritis. Can Med Assoc J. 1984 Feb 15;130(4):411–415. [PMC free article] [PubMed] [Google Scholar]
  8. Miehle W., Schattenkirchner M., Albert D., Bunge M. HLA-DR4 in ankylosing spondylitis with different patterns of joint involvement. Ann Rheum Dis. 1985 Jan;44(1):39–44. doi: 10.1136/ard.44.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Moll J. M., Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55–78. doi: 10.1016/0049-0172(73)90035-8. [DOI] [PubMed] [Google Scholar]
  10. Panayi G. S., Wooley P., Batchelor J. R. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J. 1978 Nov 11;2(6148):1326–1328. doi: 10.1136/bmj.2.6148.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tiilikainen A., Lassus A., Karvonen J., Vartiainen P., Julin M. Psoriasis and HLA-Cw6. Br J Dermatol. 1980 Feb;102(2):179–184. doi: 10.1111/j.1365-2133.1980.tb05690.x. [DOI] [PubMed] [Google Scholar]
  12. White S. H., Newcomer V. D., Mickey M. R., Terasaki P. I. Disturbance of HL-A antigen frequency in Psoriasis. N Engl J Med. 1972 Oct 12;287(15):740–743. doi: 10.1056/NEJM197210122871504. [DOI] [PubMed] [Google Scholar]

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