Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 Apr;46(4):307–313. doi: 10.1136/ard.46.4.307

Polymorphonuclear leucocyte function and previous yersinia arthritis: enhanced chemokinetic migration and oxygen radical production correlate with the severity of the acute disease.

P Koivuranta-Vaara, M Leirisalo-Repo, H Repo
PMCID: PMC1002125  PMID: 3592787

Abstract

Polymorphonuclear leucocyte (PMN) functions (migration in vitro, chemiluminescence, O-2 production, binding of chemotactic peptide, and aggregation) were studied in HLA-B27 positive patients with previous yersinia arthritis (YA). PMNs of patients whose disease had been severe showed chemokinetic and chemiluminescence responses significantly higher than the PMNs of those with a mild disease. The results support the view that enhanced PMN function contributes to inflammatory symptoms in patients with YA.

Full text

PDF
309

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. doi: 10.1084/jem.115.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bender J. G., Van Epps D. E. Analysis of the bimodal chemiluminescence pattern stimulated in human neutrophils by chemotactic factors. Infect Immun. 1983 Sep;41(3):1062–1070. doi: 10.1128/iai.41.3.1062-1070.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boyum A. Separation of blood leucocytes, granulocytes and lymphocytes. Tissue Antigens. 1974;4(4):269–274. [PubMed] [Google Scholar]
  4. Brewerton D. A. Joseph J. Bunim Memorial Lecture. HLA-B27 and the inheritance of susceptibility to rheumatic disease. Arthritis Rheum. 1976 Jul-Aug;19(4):656–668. doi: 10.1002/1529-0131(197607/08)19:4<656::aid-art1780190402>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  5. Dahinden C., Fehr J. Granulocyte activation by endotoxin. II. Role of granulocyte adherence, aggregation, and effect of cytochalasin B, and comparison with formylated chemotactic peptide-induced stimulation. J Immunol. 1983 Feb;130(2):863–868. [PubMed] [Google Scholar]
  6. Dahlgren C., Stendahl O. Effect of in vitro preincubation of polymorphonuclear leukocytes on formylmethionyl-leucyl-phenylalanine-induced chemiluminescence. Infect Immun. 1982 Jul;37(1):34–39. doi: 10.1128/iai.37.1.34-39.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Harlan J. M. Leukocyte-endothelial interactions. Blood. 1985 Mar;65(3):513–525. [PubMed] [Google Scholar]
  8. Koivuranta-Vaara P., Repo H., Leirisalo M., Kiistala U., Osterman T., Vapaatalo H. Enhanced neutrophil migration in vivo HLA B27 positive subjects. Ann Rheum Dis. 1984 Apr;43(2):181–185. doi: 10.1136/ard.43.2.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Leirisalo M., Repo H., Tiilikainen A., Kosunen T. U., Laitinen O. Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro. Arthritis Rheum. 1980 Sep;23(9):1036–1044. doi: 10.1002/art.1780230911. [DOI] [PubMed] [Google Scholar]
  10. Leirisalo M., Skylv G., Kousa M., Voipio-Pulkki L. M., Suoranta H., Nissilä M., Hvidman L., Nielsen E. D., Svejgaard A., Tilikainen A. Followup study on patients with Reiter's disease and reactive arthritis, with special reference to HLA-B27. Arthritis Rheum. 1982 Mar;25(3):249–259. doi: 10.1002/art.1780250302. [DOI] [PubMed] [Google Scholar]
  11. McGuigan L. E., Geczy A. F., Edmonds J. P. The immunopathology of ankylosing spondylitis--a review. Semin Arthritis Rheum. 1985 Nov;15(2):81–105. doi: 10.1016/0049-0172(85)90027-7. [DOI] [PubMed] [Google Scholar]
  12. Pease C. T., Fordham J. N., Currey H. L. Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27. Ann Rheum Dis. 1984 Apr;43(2):279–284. doi: 10.1136/ard.43.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pick E., Mizel D. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods. 1981;46(2):211–226. doi: 10.1016/0022-1759(81)90138-1. [DOI] [PubMed] [Google Scholar]
  14. Repo H., Jokipii A. M., Leirisalo M., Kosunen T. U. Leucocyte motility in the newborn: determination of spontaneous movement is essential in the in vitro assessment of neutrophil chemotaxis. Clin Exp Immunol. 1980 Jun;40(3):620–626. [PMC free article] [PubMed] [Google Scholar]
  15. Repo H., Kosunen T. U. Leukocyte migration agarose test for the assessment of human neutrophil chemotaxis. II. Variables in the attraction assay. Scand J Immunol. 1977;6(3):211–218. doi: 10.1111/j.1365-3083.1977.tb00386.x. [DOI] [PubMed] [Google Scholar]
  16. Repo H., Leirisalo-Repo M., Skurnik M., Tiilikainen A. Neutrophil function and HLA-B27. Superoxide production and yersinicidal activity of neutrophils from patients with previous yersinia arthritis. Med Biol. 1984;62(2):91–94. [PubMed] [Google Scholar]
  17. Repo H., Leirisalo M., Koivuranta P., Osterman T., Kiistala U., Gahmberg C. G., Vapaatalo H., Tiilikainen A., Laitinen O. Neutrophil function and HLA-B27. Br J Rheumatol. 1983 Nov;22(4 Suppl 2):168–171. doi: 10.1093/rheumatology/xxii.suppl_2.168. [DOI] [PubMed] [Google Scholar]
  18. Repo H., Leirisalo M., Tiilikainen A., Laitinen O. Chemotaxis in yersinia arthritis. In vitro stimulation of neutrophil migration by HLA--B27 positive and negative sera. Arthritis Rheum. 1982 Jun;25(6):655–661. doi: 10.1002/art.1780250608. [DOI] [PubMed] [Google Scholar]
  19. Rosenbaum J. T. Why HLA-B27: an analysis based on two animal models. Ann Intern Med. 1981 Feb;94(2):261–263. doi: 10.7326/0003-4819-94-2-261. [DOI] [PubMed] [Google Scholar]
  20. Williams L. T., Snyderman R., Pike M. C., Lefkowitz R. J. Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1204–1208. doi: 10.1073/pnas.74.3.1204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zigmond S. H., Hirsch J. G. Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973 Feb 1;137(2):387–410. doi: 10.1084/jem.137.2.387. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES