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. 1987 May;46(5):380–384. doi: 10.1136/ard.46.5.380

Relation between bone erosions and rheumatoid factor isotypes.

J A Arnason, T Jónsson, A Brekkan, K Sigurjónsson, H Valdimarsson
PMCID: PMC1002145  PMID: 3592799

Abstract

Total rheumatoid factor (RF) activity and individual RF isotypes were measured in 62 patients with rheumatic diseases. Retrospective analysis of available x rays showed an association between IgA RF and the occurrence of periarticular bone erosions in hands. In contrast, IgG RF and IgM RF did not show any significant association with erosions. Furthermore, a close correlation was observed between the RF isotype levels in simultaneously drawn serum and synovial fluid samples. The possible significance of IgA RF in the pathogenesis of bone erosions is discussed.

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Selected References

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