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. 1987 Jun;46(6):431–435. doi: 10.1136/ard.46.6.431

Evidence for both histamine H1 and H2 receptors on human articular chondrocytes.

D J Taylor, D E Woolley
PMCID: PMC1002160  PMID: 2820319

Abstract

Using specific histamine H1 and H2 receptor antagonists, evidence is presented for the existence of both H1 and H2 receptors on human articular chondrocytes in vitro. Stimulation of the H1 receptor by histamine (range 0.18 to 17.8 mumol/l) significantly increased prostaglandin E (PGE) production, while activation of the histamine H2 receptor increased intracellular cyclic adenosine-5'-monophosphate (AMP). The histamine H1 antagonists mepyramine and tripelennamine blocked the histamine induced increase in PGE production, and the H2 antagonists cimetidine and ranitidine prevented the increase in intracellular cyclic AMP. These observations suggest that mast cell-chondrocyte interactions mediated via histamine may contribute to some of the pathophysiological changes observed in joint disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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