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. 1988 Mar;47(3):198–205. doi: 10.1136/ard.47.3.198

Bone resorbing activity in synovial fluids in destructive osteoarthritis and rheumatoid arthritis.

W H Alwan 1, P A Dieppe 1, C J Elson 1, J W Bradfield 1
PMCID: PMC1003483  PMID: 3258503

Abstract

The synovial fluids of patients with a destructive form of osteoarthritis (DOA) were shown to contain high levels of bone resorbing activity as judged by the ability of the fluid to stimulate the release of 45Ca from labelled cultured mouse calvariae. The activity was lost on extended storage of the synovial fluids and was dependent for its effect on cellular activity in bone. Bone resorbing activity was present in most synovial fluids from patients with DOA and rheumatoid arthritis (RA) but occurred at higher levels in the former. In contrast, interleukin 1 (IL1) activity, measured by the mouse thymocytes costimulation assay, was higher in RA than DOA synovial fluids. Little or no bone resorbing or IL1 activity was detected in synovial fluids from patients with pseudogout or non-destructive osteoarthritis. These results suggest that most DOA synovial fluids contain a bone resorbing factor other than IL1. It is considered that the factor may be produced by synovial cells stimulated by hydroxyapatite crystals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNICOT N. A. The local action of vitamin A on bone. J Anat. 1950 Oct;84(4):374–387. [PMC free article] [PubMed] [Google Scholar]
  2. Bendtzen K., Petersen J., Halkjaer-Kristensen J., Ingemann-Hansen T. Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis. Rheumatol Int. 1985;5(2):79–82. doi: 10.1007/BF00270301. [DOI] [PubMed] [Google Scholar]
  3. Bertolini D. R., Nedwin G. E., Bringman T. S., Smith D. D., Mundy G. R. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature. 1986 Feb 6;319(6053):516–518. doi: 10.1038/319516a0. [DOI] [PubMed] [Google Scholar]
  4. Bockman R. S., Repo M. A. Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis. J Exp Med. 1981 Aug 1;154(2):529–534. doi: 10.1084/jem.154.2.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cheung H. S., Halverson P. B., McCarty D. J. Release of collagenase, neutral protease, and prostaglandins from cultured mammalian synovial cells by hydroxyapatite and calcium pyrophosphate dihydrate crystals. Arthritis Rheum. 1981 Nov;24(11):1338–1344. doi: 10.1002/art.1780241102. [DOI] [PubMed] [Google Scholar]
  6. Dayer J. M., de Rochemonteix B., Burrus B., Demczuk S., Dinarello C. A. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest. 1986 Feb;77(2):645–648. doi: 10.1172/JCI112350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dieppe P., Watt I. Crystal deposition in osteoarthritis: an opportunistic event? Clin Rheum Dis. 1985 Aug;11(2):367–392. [PubMed] [Google Scholar]
  8. Doherty M., Holt M., MacMillan P., Watt I., Dieppe P. A reappraisal of 'analgesic hip'. Ann Rheum Dis. 1986 Apr;45(4):272–276. doi: 10.1136/ard.45.4.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fontana A., Hengartner H., Weber E., Fehr K., Grob P. J., Cohen G. Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis. Rheumatol Int. 1982;2(2):49–53. doi: 10.1007/BF00541245. [DOI] [PubMed] [Google Scholar]
  10. Gery I., Gershon R. K., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. J Exp Med. 1972 Jul 1;136(1):128–142. doi: 10.1084/jem.136.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gowen M., Wood D. D., Ihrie E. J., McGuire M. K., Russell R. G. An interleukin 1 like factor stimulates bone resorption in vitro. Nature. 1983 Nov 24;306(5941):378–380. doi: 10.1038/306378a0. [DOI] [PubMed] [Google Scholar]
  12. Gowen M., Wood D. D., Ihrie E. J., Meats J. E., Russell R. G. Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim Biophys Acta. 1984 Feb 14;797(2):186–193. doi: 10.1016/0304-4165(84)90121-1. [DOI] [PubMed] [Google Scholar]
  13. Halverson P. B., McCarty D. J., Cheung H. S., Ryan L. M. Milwaukee Shoulder syndrome: eleven additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease). Semin Arthritis Rheum. 1984 Aug;14(1):36–44. doi: 10.1016/0049-0172(84)90007-6. [DOI] [PubMed] [Google Scholar]
  14. Heath J. K., Saklatvala J., Meikle M. C., Atkinson S. J., Reynolds J. J. Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tissue Int. 1985 Jan;37(1):95–97. doi: 10.1007/BF02557686. [DOI] [PubMed] [Google Scholar]
  15. Klein D. C., Raisz L. G. Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology. 1970 Jun;86(6):1436–1440. doi: 10.1210/endo-86-6-1436. [DOI] [PubMed] [Google Scholar]
  16. Malawista S. E., Duff G. W., Atkins E., Cheung H. S., McCarty D. J. Crystal-induced endogenous pyrogen production. A further look at gouty inflammation. Arthritis Rheum. 1985 Sep;28(9):1039–1046. doi: 10.1002/art.1780280911. [DOI] [PubMed] [Google Scholar]
  17. McCarty D. J., Cheung H. S. Prostaglandin (PG) E2 generation by cultured canine synovial fibroblasts exposed to microcrystals containing calcium. Ann Rheum Dis. 1985 May;44(5):316–320. doi: 10.1136/ard.44.5.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  19. Richardson H. J., Elford P. R., Sharrard R. M., Meats J. E., Russell R. G. Modulation of connective tissue metabolism by partially purified human interleukin 1. Cell Immunol. 1985 Jan;90(1):41–51. doi: 10.1016/0008-8749(85)90167-4. [DOI] [PubMed] [Google Scholar]
  20. Rønningen H., Langeland N. Indomethacin treatment in osteoarthritis of the hip joint. Does the treatment interfere with the natural course of the disease? Acta Orthop Scand. 1979 Apr;50(2):169–174. doi: 10.3109/17453677908989752. [DOI] [PubMed] [Google Scholar]

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