Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1988 Jul;47(7):542–545. doi: 10.1136/ard.47.7.542

Autonomic neuropathy in systemic sclerosis.

P S Klimiuk 1, L Taylor 1, R D Baker 1, M I Jayson 1
PMCID: PMC1003567  PMID: 3401050

Abstract

Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in the CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) variant and also in those patients with diffuse involvement. There was sympathetic and parasympathetic dysfunction. These findings suggest that autonomic neuropathy is a feature of systemic sclerosis.

Full text

PDF
543

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett T., Hosking D. J., Hampton J. R. Cardiovascular control in diabetes mellitus. Br Med J. 1975 Jun 14;2(5971):585–587. doi: 10.1136/bmj.2.5971.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clarke B. F., Ewing D. J., Campbell I. W. Diabetic autonomic neuropathy. Diabetologia. 1979 Oct;17(4):195–212. doi: 10.1007/BF01235856. [DOI] [PubMed] [Google Scholar]
  3. Di Trapani G., Pocchiari M., Masullo C., Albanese A., Tulli A. Peripheral neuropathy in the course of progressive systemic sclerosis: light and ultrastructural study. Ital J Neurol Sci. 1982 Dec;3(4):341–348. doi: 10.1007/BF02043583. [DOI] [PubMed] [Google Scholar]
  4. Edmonds M. E., Jones T. C., Saunders W. A., Sturrock R. D. Autonomic neuropathy in rheumatoid arthritis. Br Med J. 1979 Jul 21;2(6183):173–175. doi: 10.1136/bmj.2.6183.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ewing D. J. Cardiovascular reflexes and autonomic neuropathy. Clin Sci Mol Med. 1978 Oct;55(4):321–327. doi: 10.1042/cs0550321. [DOI] [PubMed] [Google Scholar]
  6. KIBLER R. F., ROSE F. C. Peripheral neuropathy in the "collagen diseases": a case of scleroderma neuropathy. Br Med J. 1960 Jun 11;1(5188):1781–1784. doi: 10.1136/bmj.1.5188.1781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Leden I., Eriksson A., Lilja B., Sturfelt G., Sundkvist G. Autonomic nerve function in rheumatoid arthritis of varying severity. Scand J Rheumatol. 1983;12(2):166–170. doi: 10.3109/03009748309102905. [DOI] [PubMed] [Google Scholar]
  8. Lloyd-Mostyn R. H., Watkins P. J. Defective innervation of heart in diabetic autonomic neuropathy. Br Med J. 1975 Jul 5;3(5974):15–17. doi: 10.1136/bmj.3.5974.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. ORMEA F. Studio comparativo del sistema neuro-vegetativo periferico nella sclerodermia diffusa e nel tessuto connettivale alterato di alcune dermatosi. Dermatologica. 1952;105(1):8–17. [PubMed] [Google Scholar]
  10. ORMEA F. Sur la pathogénie neurovégétative de la maladie sclerodermique. Arch Belg Dermatol Syphiligr. 1958 Dec;14(4):423–432. [PubMed] [Google Scholar]
  11. PAWLOWSKI A. THE NERVE NETWORK OF THE SKIN IN DIFFUSE SCLERODERMA AND CLINICALLY SIMILAR CONDITIONS. Arch Dermatol. 1963 Dec;88:868–873. doi: 10.1001/archderm.1963.01590240192032. [DOI] [PubMed] [Google Scholar]
  12. Sonnex C., Paice E., White A. G. Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients. Ann Rheum Dis. 1986 Nov;45(11):957–960. doi: 10.1136/ard.45.11.957. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES