Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1988 Dec;47(12):1004–1007. doi: 10.1136/ard.47.12.1004

Immunoglobulin A in the skin of patients with ankylosing spondylitis.

A Collado 1, R Sanmarti 1, I Bielsa 1, T Castel 1, E Kanterewicz 1, J D Cañete 1, M A Brancós 1, J Rotes-Querol 1
PMCID: PMC1003655  PMID: 3061367

Abstract

Cutaneous immunofluorescence studies were carried out in 21 patients with ankylosing spondylitis (AS) and the results compared with those for 18 healthy subjects. The most prominent finding was the presence of IgA in dermal vessels of patients with AS (71% compared with 17% of the control group). IgG and IgM cutaneous deposits were also observed in patients with AS, but these results did not differ from those of the control group. A renal biopsy was performed in three of the patients presenting with unexplained microscopic haematuria. One of them had an IgA nephropathy, but no correlation was found between kidney and skin deposits of IgA. These findings suggest that IgA cutaneous deposits in AS are not a marker of IgA nephropathy but stress the role of immunoglobulin A in the pathogenesis of this disease.

Full text

PDF
1007

Images in this article

1005Image
on p.1005
1005Image
on p.1005

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D. Ankylosing spondylitis and HL-A 27. Lancet. 1973 Apr 28;1(7809):904–907. doi: 10.1016/s0140-6736(73)91360-3. [DOI] [PubMed] [Google Scholar]
  2. Bruneau C., Villiaumey J., Avouac B., Martigny J., Laurent J., Pichot A., Belghiti D., Lagrue G. Seronegative spondyloarthropathies and IgA glomerulonephritis: a report of four cases and a review of the literature. Semin Arthritis Rheum. 1986 Feb;15(3):179–184. doi: 10.1016/0049-0172(86)90015-6. [DOI] [PubMed] [Google Scholar]
  3. Collado A., Sanmarti R., Brancós M. A., Kanterewicz E., Gallart T., Rotés-Querol J., Cobos A. Immunoglobulin A and C reactive protein levels in ankylosing spondylitis. Ann Rheum Dis. 1987 Sep;46(9):719–720. doi: 10.1136/ard.46.9.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fitzgerald O. M., Barnes L., Woods R., McHugh L., Barry C., O'Loughlin S. Direct immunofluorescence of normal skin in rheumatoid arthritis. Br J Rheumatol. 1985 Nov;24(4):340–345. doi: 10.1093/rheumatology/24.4.340. [DOI] [PubMed] [Google Scholar]
  6. Franssen M. J., van de Putte L. B., Gribnau F. W. IgA serum levels and disease activity in ankylosing spondylitis: a prospective study. Ann Rheum Dis. 1985 Nov;44(11):766–771. doi: 10.1136/ard.44.11.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hené R. J., Velthuis P., van de Wiel A., Klepper D., Dorhout Mees E. J., Kater L. The relevance of IgA deposits in vessel walls of clinically normal skin. A prospective study. Arch Intern Med. 1986 Apr;146(4):745–749. doi: 10.1001/archinte.1986.00360160177024. [DOI] [PubMed] [Google Scholar]
  8. McGill P. E., Brougham P. A., Tulloch J. Immune deposits in the skin of patients with rheumatoid arthritis. J Rheumatol. 1984 Aug;11(4):454–456. [PubMed] [Google Scholar]
  9. McGuigan L. E., Geczy A. F., Edmonds J. P. The immunopathology of ankylosing spondylitis--a review. Semin Arthritis Rheum. 1985 Nov;15(2):81–105. doi: 10.1016/0049-0172(85)90027-7. [DOI] [PubMed] [Google Scholar]
  10. Nieboer C. Immunofluorescence patterns in sun-exposed and not-sun-exposed skin of healthy individuals. Acta Derm Venereol. 1981;61(6):471–479. [PubMed] [Google Scholar]
  11. Rajaraman S., Goldblum R. M., Cavallo T. IgA-associated glomerulonephritides: a study with monoclonal antibodies. Clin Immunol Immunopathol. 1986 Jun;39(3):514–522. doi: 10.1016/0090-1229(86)90178-9. [DOI] [PubMed] [Google Scholar]
  12. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  13. Shu K. H., Lian J. D., Yang Y. F., Lu Y. S., Wang J. Y., Lan J. L., Chou G. Glomerulonephritis in ankylosing spondylitis. Clin Nephrol. 1986 Apr;25(4):169–174. [PubMed] [Google Scholar]
  14. Swaak A. J., Frankfort I., Menon R. S., Pekelharing J. M., Planten O. Absence of IgA nephropathy in patients with ankylosing spondylitis. Rheumatol Int. 1986;6(4):145–149. doi: 10.1007/BF00541280. [DOI] [PubMed] [Google Scholar]
  15. Wall B. A., Agudelo C. A., Pisko E. J. Increased incidence of recurrent hematuria in ankylosing spondylitis: a possible association with IgA nephropathy. Rheumatol Int. 1984;4(1):27–29. doi: 10.1007/BF00683881. [DOI] [PubMed] [Google Scholar]
  16. Westedt M. L., Vermeer B. J., Meijer C. J., Daha M. R., Baldwin W. M., 3rd, Cats A. Immunopathological abnormalities in the normal skin of patients with rheumatoid arthritis in relation to clinical and serological findings: a one year follow up study. Ann Rheum Dis. 1987 Mar;46(3):213–218. doi: 10.1136/ard.46.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Woo K. T., Edmondson R. P., Lee E. J., Chiang G. S., Lim C. H. Significance of microhaematuria in young adults. Br Med J (Clin Res Ed) 1984 Mar 17;288(6420):861–861. doi: 10.1136/bmj.288.6420.861. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES