Abstract
The spectrum of rheumatoid arthritis (RA) was studied in a group of 52 blacks who attended a rheumatology unit in Cape Town, South Africa. The mean age of the patients was 44.6 years, and the female to male ratio was 3.7:1. Significant radiographic changes were frequently noted, and the mean Larsen scores were 34.9 for the hands, 19.6 for the feet, and 6.6 for the wrists. About two thirds of the patients had received an immunomodulatory drug and 20 (38%) had had one or more surgical procedures for their RA. Anaemia was the commonest extra-articular manifestation, and although the other extra-articular features were uncommon, a variety of features had been detected during the course of the disease. Earlier studies on blacks in Africa suggested that RA was a mild disease; our findings, however, are in agreement with the more recent surveys, which suggest that severe disease is not uncommon.
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- Anderson I. F. Rheumatoid arthritis in the Bantu. S Afr Med J. 1970 Oct 31;44(43):1227–1229. [PubMed] [Google Scholar]
- Bagg L. R., Hansen D. P., Lewis C., Houba V. Rheumatoid arthritis in Kenya. I. Clinical observations. Ann Rheum Dis. 1979 Feb;38(1):23–25. doi: 10.1136/ard.38.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beighton P., Solomon L., Valkenburg H. A. Rheumatoid arthritis in a rural South African Negro population. Ann Rheum Dis. 1975 Apr;34(2):136–141. doi: 10.1136/ard.34.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cockel R., Kendall M. J., Becker J. F., Hawkins C. F. Serum biochemical values in rheumatoid disease. Ann Rheum Dis. 1971 Mar;30(2):166–170. doi: 10.1136/ard.30.2.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DUTHIE J. J., THOMPSON M., WEIR M. M., FLETCHER W. B. Medical and social aspects of the treatment of rheumatoid arthritis; with special reference to factors affecting prognosis. Ann Rheum Dis. 1955 Jun;14(2):133–149. doi: 10.1136/ard.14.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gelfand M. "Medical" arthritis in African practice. Cent Afr J Med. 1969 Jun;15(6):131–135. [PubMed] [Google Scholar]
- Gordon D. A., Stein J. L., Broder I. The extra-articular features of rheumatoid arthritis. A systematic analysis of 127 cases. Am J Med. 1973 Apr;54(4):445–452. doi: 10.1016/0002-9343(73)90040-5. [DOI] [PubMed] [Google Scholar]
- Greenwood B. M. Polyarthritis in Western Nigeria. I. Rheumatoid arthritis. Ann Rheum Dis. 1969 Sep;28(5):488–496. doi: 10.1136/ard.28.5.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HALL L. POLYARTHRITIS IN NAIROBI AFRICANS. East Afr Med J. 1963 Jul;40:354–358. [PubMed] [Google Scholar]
- Hansen T. M., Hansen N. E., Birgens H. S., Hølund B., Lorenzen I. Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis. Scand J Rheumatol. 1983;12(4):353–359. doi: 10.3109/03009748309099740. [DOI] [PubMed] [Google Scholar]
- Kanyerezi B. R., Baddeley H., Kisumba D. Rheumatoid arthritis in Ugandan Africans. Ann Rheum Dis. 1970 Nov;29(6):617–621. doi: 10.1136/ard.29.6.617. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsen A., Dale K., Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 1977 Jul;18(4):481–491. doi: 10.1177/028418517701800415. [DOI] [PubMed] [Google Scholar]
- Meyers O. L., Daynes G., Beighton P. Rheumatoid arthritis in a tribal Xhosa population in the Transkei, Southern Africa. Ann Rheum Dis. 1977 Feb;36(1):62–65. doi: 10.1136/ard.36.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moolenburgh J. D., Moore S., Valkenburg H. A., Erasmus M. G. Rheumatoid arthritis in Lesotho. Ann Rheum Dis. 1984 Feb;43(1):40–43. doi: 10.1136/ard.43.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moolenburgh J. D., Valkenburg H. A., Fourie P. B. A population study on rheumatoid arthritis in Lesotho, southern Africa. Ann Rheum Dis. 1986 Aug;45(8):691–695. doi: 10.1136/ard.45.8.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mowat A. G. Hematologic abnormalities in rheumatoid arthritis. Semin Arthritis Rheum. 1972 Winter;1(3):195–219. doi: 10.1016/0049-0172(72)90001-7. [DOI] [PubMed] [Google Scholar]
- POLLAK V. E. ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. N Engl J Med. 1964 Jul 23;271:165–171. doi: 10.1056/NEJM196407232710401. [DOI] [PubMed] [Google Scholar]
- Percy-Lancaster R. Arthritis survey in the Transkei and Ciskei. S Afr Med J. 1974 Nov 23;48(57):2355–2356. [PubMed] [Google Scholar]
- Pruzanski W., Russell M. L., Gordon D. A., Ogryzlo M. A. Serum and synovial fluid proteins in rheumatoid arthritis and degenerative joint diseases. Am J Med Sci. 1973 Jun;265(6):483–490. doi: 10.1097/00000441-197306000-00007. [DOI] [PubMed] [Google Scholar]
- ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
- Scott D. L., Dawes P. T., Fowler P. D., Grindulis K. A., Shadforth M., Bacon P. A. Anti-rheumatic drugs and joint damage in rheumatoid arthritis. Q J Med. 1985 Jan;54(213):49–59. [PubMed] [Google Scholar]
- Solomon L., Robin G., Valkenburg H. A. Rheumatoid arthritis in an urban South African Negro population. Ann Rheum Dis. 1975 Apr;34(2):128–135. doi: 10.1136/ard.34.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tilve G. H., Lengade J. K., Nair K. G., Bavadekar A. V., Baxi A. J., Shah R. C. Serum immunoglobulin status in rheumatoid arthritis. J Indian Med Assoc. 1977 Jul 16;69(2):25–26. [PubMed] [Google Scholar]
- Webb J., Whaley K., MacSween R. N., Nuki G., Dick W. C., Buchanan W. W. Liver disease in rheumatoid arthritis and Sjøgren's syndrome. Prospective study using biochemical and serological markers of hepatic dysfunction. Ann Rheum Dis. 1975 Feb;34(1):70–81. doi: 10.1136/ard.34.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]