Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1989 Apr;48(4):281–286. doi: 10.1136/ard.48.4.281

Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes.

P Geborek 1, K Forslind 1, F A Wollheim 1
PMCID: PMC1003742  PMID: 2653243

Abstract

A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.

Full text

PDF
281

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen R. E., Outhwaite J. M., Morris C. J., Blake D. R. Xanthine oxidoreductase is present in human synovium. Ann Rheum Dis. 1987 Nov;46(11):843–845. doi: 10.1136/ard.46.11.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brothers G. B., Jr, Hadler N. M. Diurnal variations in rheumatoid synovial effusions. J Rheumatol. 1983 Jun;10(3):471–474. [PubMed] [Google Scholar]
  3. CAUGHEY D. E., BYWATERS E. G. Joint fluid pressure in chronic knee effusions. Ann Rheum Dis. 1963 Mar;22:106–109. doi: 10.1136/ard.22.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEANDRADE J. R., GRANT C., DIXON A. S. JOINT DISTENSION AND REFLEX MUSCLE INHIBITION IN THE KNEE. J Bone Joint Surg Am. 1965 Mar;47:313–322. [PubMed] [Google Scholar]
  5. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
  6. Falchuk K. H., Goetzl E. J., Kulka J. P. Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med. 1970 Aug;49(2):223–231. doi: 10.1016/s0002-9343(70)80078-x. [DOI] [PubMed] [Google Scholar]
  7. Geborek P., Lindoff B., Valind S. O. Measurement of oxygen and carbon dioxide partial pressures in synovial fluid after tonometry. Clin Physiol. 1988 Aug;8(4):427–432. doi: 10.1111/j.1475-097x.1988.tb00286.x. [DOI] [PubMed] [Google Scholar]
  8. Goetzi E. J., Rynes R. I., Stillman J. S. Abnormalities of respiratory gases in synovial fluid of patients with juvenile rheumatoid arthritis. Arthritis Rheum. 1974 Jul-Aug;17(4):450–454. doi: 10.1002/art.1780170416. [DOI] [PubMed] [Google Scholar]
  9. Goetzl E. J., Falchuk K. H., Zeiger L. S., Sullivan A. L., Hebert C. L., Adams J. P., Decker J. L. A physiological approach to the assessment of disease activity in rheumatoid arthritis. J Clin Invest. 1971 Jun;50(6):1167–1180. doi: 10.1172/JCI106594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jayson MISt Dixon A. J. Intra-articular pressure in rheumatoid arthritis of the knee. II. Effect of intra-articular pressure on blood circulation to the synovium. Ann Rheum Dis. 1970 May;29(3):266–268. doi: 10.1136/ard.29.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jayson M. I., Dixon A. S. Intra-articular pressure in rheumatoid arthritis of the knee. 3. Pressure changes during joint use. Ann Rheum Dis. 1970 Jul;29(4):401–408. doi: 10.1136/ard.29.4.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jayson M. I., St Dixon A. J. Intra-articular pressure in rheumatoid arthritis of the knee. I. Pressure changes during passive joint distension. Ann Rheum Dis. 1970 May;29(3):261–265. doi: 10.1136/ard.29.3.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lund-Olesen K. Oxygen tension in synovial fluids. Arthritis Rheum. 1970 Nov-Dec;13(6):769–776. doi: 10.1002/art.1780130606. [DOI] [PubMed] [Google Scholar]
  14. Myers D. B., Palmer D. G. Capsular compliance and pressure-volume relationships in normal and arthritic knees. J Bone Joint Surg Br. 1972 Nov;54(4):710–716. [PubMed] [Google Scholar]
  15. Niinikoski J., Einola S. Postoperative synovial fluid. Metabolic response to meniscectomy or synovectomy. Acta Orthop Scand. 1977;48(2):129–137. doi: 10.3109/17453677708985123. [DOI] [PubMed] [Google Scholar]
  16. Nilsson G. E., Tenland T., Oberg P. A. Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng. 1980 Oct;27(10):597–604. doi: 10.1109/TBME.1980.326582. [DOI] [PubMed] [Google Scholar]
  17. Nilsson G. E., Tenland T., Obert P. A. A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy. IEEE Trans Biomed Eng. 1980 Jan;27(1):12–19. doi: 10.1109/TBME.1980.326686. [DOI] [PubMed] [Google Scholar]
  18. Palmer D. G., Myers D. B. Some observations of joint effusions. Arthritis Rheum. 1968 Dec;11(6):745–755. doi: 10.1002/art.1780110604. [DOI] [PubMed] [Google Scholar]
  19. Phelps P., Steele A. D., McCarty D. J. Significance of xenon-133 clearance rate from canine and human joints. Arthritis Rheum. 1972 Jul-Aug;15(4):360–370. doi: 10.1002/art.1780150407. [DOI] [PubMed] [Google Scholar]
  20. Richman A. I., Su E. Y., Ho G., Jr Reciprocal relationship of synovial fluid volume and oxygen tension. Arthritis Rheum. 1981 May;24(5):701–705. doi: 10.1002/art.1780240512. [DOI] [PubMed] [Google Scholar]
  21. Simkin P. A. Synovial permeability in rheumatoid arthritis. Arthritis Rheum. 1979 Jul;22(7):689–696. doi: 10.1002/art.1780220701. [DOI] [PubMed] [Google Scholar]
  22. Tenland T., Salerud E. G., Nilsson G. E., Oberg P. A. Spatial and temporal variations in human skin blood flow. Int J Microcirc Clin Exp. 1983;2(2):81–90. [PubMed] [Google Scholar]
  23. Treuhaft P. S., MCCarty D. J. Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum. 1971 Jul-Aug;14(4):475–484. doi: 10.1002/art.1780140407. [DOI] [PubMed] [Google Scholar]
  24. Wallis W. J., Simkin P. A., Nelp W. B. Low synovial clearance of iodide provides evidence of hypoperfusion in chronic rheumatoid synovitis. Arthritis Rheum. 1985 Oct;28(10):1096–1104. doi: 10.1002/art.1780281004. [DOI] [PubMed] [Google Scholar]
  25. Woodruff T., Blake D. R., Freeman J., Andrews F. J., Salt P., Lunec J. Is chronic synovitis an example of reperfusion injury? Ann Rheum Dis. 1986 Jul;45(7):608–611. doi: 10.1136/ard.45.7.608. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES