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. 1989 Jul;48(7):535–538. doi: 10.1136/ard.48.7.535

Effects of low dose corticosteroids on bone mass in rheumatoid arthritis: a longitudinal study.

P N Sambrook 1, M L Cohen 1, J A Eisman 1, N A Pocock 1, G D Champion 1, M G Yeates 1
PMCID: PMC1003811  PMID: 2774695

Abstract

Low dose corticosteroids are effective in suppressing synovitis in rheumatoid arthritis (RA), but there remains concern about their side effects, particularly osteoporosis. To examine the effects of low dose corticosteroids on bone loss in RA bone mineral density (BMD) was measured in the lumbar spine and hip for up to two years in 15 patients treated with these agents (mean dose prednis(ol)one 6.6 mg/day). 15 patients not receiving them, and 15 age matched controls. The initial BMD at both skeletal sites was significantly reduced in both patient groups compared with controls. The mean change in bone density was 0.2, 0.1, and -0.1% a year in the spine and -2.0, -1.9, and -1.0% a year in the hip respectively for the three groups. These rates of bone loss were not significantly different between groups at either site. These findings suggest that low dose corticosteroid treatment in RA is not associated with an increased risk of osteoporosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Als O. S., Gotfredsen A., Christiansen C. The effect of glucocorticoids on bone mass in rheumatoid arthritis patients. Influence of menopausal state. Arthritis Rheum. 1985 Apr;28(4):369–375. doi: 10.1002/art.1780280403. [DOI] [PubMed] [Google Scholar]
  2. Buchanan W. W., Samuels B. M., Jasani M. K., Anderson J. A., O'Brien W. M., Boyle J. A., Nuki G., Boyle I. T. Do oral corticosteroids cause osteoporosis in rheumatoid arthritis? Ann Rheum Dis. 1970 Sep;29(5):560–561. doi: 10.1136/ard.29.5.560-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Byron M. A., Kirwan J. R. Corticosteroids in rheumatoid arthritis: is a trial of their 'disease modifying' potential feasible? Ann Rheum Dis. 1986 Feb;45(2):171–173. doi: 10.1136/ard.45.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kennedy A. C., Boddy K., Williams E. D., Elliott A. T., Harvey I., Holloway I., Haywood J. K. Whole body elemental composition during drug treatment of rheumatoid arthritis: a preliminary study. Ann Rheum Dis. 1979 Apr;38(2):137–140. doi: 10.1136/ard.38.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Masi A. T. Low dose glucocorticoid therapy in rheumatoid arthritis (RA): transitional or selected add-on therapy? J Rheumatol. 1983 Oct;10(5):675–678. [PubMed] [Google Scholar]
  6. Mueller M. N., Jurist J. M. Skeletal status in rheumatoid arthritis. A preliminary report. Arthritis Rheum. 1973 Jan-Feb;16(1):66–70. doi: 10.1002/art.1780160110. [DOI] [PubMed] [Google Scholar]
  7. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  8. Reid D. M., Kennedy N. S., Smith M. A., Tothill P., Nuki G. Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):330–332. doi: 10.1136/bmj.285.6338.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Riggs B. L., Wahner H. W., Seeman E., Offord K. P., Dunn W. L., Mazess R. B., Johnson K. A., Melton L. J., 3rd Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. 1982 Oct;70(4):716–723. doi: 10.1172/JCI110667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sambrook P. N., Eisman J. A., Champion G. D., Pocock N. A. Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 1988 Aug;31(8):973–978. doi: 10.1002/art.1780310805. [DOI] [PubMed] [Google Scholar]
  11. Sambrook P. N., Eisman J. A., Champion G. D., Yeates M. G., Pocock N. A., Eberl S. Determinants of axial bone loss in rheumatoid arthritis. Arthritis Rheum. 1987 Jul;30(7):721–728. doi: 10.1002/art.1780300701. [DOI] [PubMed] [Google Scholar]
  12. Sambrook P. N., Eisman J. A., Yeates M. G., Pocock N. A., Eberl S., Champion G. D. Osteoporosis in rheumatoid arthritis: safety of low dose corticosteroids. Ann Rheum Dis. 1986 Nov;45(11):950–953. doi: 10.1136/ard.45.11.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Saville P. D., Kharmosh O. Osteoporosis of rheumatoid arthritis: influence of age, sex and corticosteroids. Arthritis Rheum. 1967 Oct;10(5):423–430. doi: 10.1002/art.1780100504. [DOI] [PubMed] [Google Scholar]
  14. Verstraeten A., Dequeker J. Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: effect of low dose corticosteroids. Ann Rheum Dis. 1986 Oct;45(10):852–857. doi: 10.1136/ard.45.10.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. de Deuxchaisnes C. N., Devogelaer J. P., Esselinckx W., Bouchez B., Depresseux G., Rombouts-Lindemans C., Huaux J. P. The effect of low dosage glucocorticoids on bone mass in rheumatoid arthritis: a cross-sectional and a longitudinal study using single photon absorptiometry. Adv Exp Med Biol. 1984;171:209–239. [PubMed] [Google Scholar]

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