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. 1991 Sep;50(9):631–633. doi: 10.1136/ard.50.9.631

Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol.

T Yamamoto 1, Y Moriwaki 1, S Takahashi 1, M Suda 1, K Higashino 1
PMCID: PMC1004507  PMID: 1929586

Abstract

The effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol were investigated. Pyrazinamide decreased the mean (SEM) fractional clearance of oxypurinol from 19.2 (2.1) to 8.8 (1.5). Probenecid increased the fractional clearance of oxypurinol from 14.1 (3.5) to 24.8 (4.1). Benzbromarone increased the fractional clearance of oxypurinol from 15.6 (2.3) to 33.8 (2.8). These results suggest that oxypurinol may be secreted by 'an organic acid system' and that oxypurinol is reabsorbed at a putative postsecretory site of the renal tubules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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