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. 1991 Oct;50(10):673–676. doi: 10.1136/ard.50.10.673

Immunohistological analysis of the synovial membrane: search for predictors of the clinical course in rheumatoid arthritis.

M Soden 1, M Rooney 1, A Whelan 1, C Feighery 1, B Bresnihan 1
PMCID: PMC1004527  PMID: 1958087

Abstract

Immunohistological features which might predict the clinical course and outcome of rheumatoid arthritis were sought by examining multiple synovial membrane samples obtained by needle biopsy from the knee joints of 57 patients who had not received disease modifying antirheumatic drugs. Clinical measurements, but not biopsies, were repeated one year and three years after starting treatment. A correlation between both the intensity of synovial lining layer thickening and mononuclear cell infiltration and the clinical status at the time of biopsy was seen. After three years of treatment the correlations were maintained in patients who had presented and persisted with milder disease but not in patients who had presented with more active disease.

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Selected References

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  1. DUTHIE J. J., THOMPSON M., WEIR M. M., FLETCHER W. B. Medical and social aspects of the treatment of rheumatoid arthritis; with special reference to factors affecting prognosis. Ann Rheum Dis. 1955 Jun;14(2):133–149. doi: 10.1136/ard.14.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Henderson B., Pettipher E. R. The synovial lining cell: biology and pathobiology. Semin Arthritis Rheum. 1985 Aug;15(1):1–32. doi: 10.1016/0049-0172(85)90007-1. [DOI] [PubMed] [Google Scholar]
  3. Henderson D. R., Jayson M. I., Tribe C. R. Lack of correlation of synovial histology with joint damage in rheumatoid arthritis. Ann Rheum Dis. 1975 Feb;34(1):7–11. doi: 10.1136/ard.34.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Howat D. W., Glynn L. E., Bitensky L., Chayen J. The origin of the apparent synovial lining cell hyperplasia in rheumatoid arthritis: evidence for a deep stem cell. Br J Exp Pathol. 1987 Apr;68(2):259–266. [PMC free article] [PubMed] [Google Scholar]
  5. Hutchinson R. M., Davis P., Jayson M. I. Thrombocytosis in rheumatoid arthritis. Ann Rheum Dis. 1976 Apr;35(2):138–142. doi: 10.1136/ard.35.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Iguchi T., Ziff M. Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation. J Clin Invest. 1986 Feb;77(2):355–361. doi: 10.1172/JCI112312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ishikawa H., Ziff M. Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane. Arthritis Rheum. 1976 Jan-Feb;19(1):1–14. doi: 10.1002/art.1780190101. [DOI] [PubMed] [Google Scholar]
  8. Jacoby R. K., Jayson M. I., Cosh J. A. Onset, early stages, and prognosis of rheumatoid arthritis: a clinical study of 100 patients with 11-year follow-up. Br Med J. 1973 Apr 14;2(5858):96–100. doi: 10.1136/bmj.2.5858.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Klareskog L., Forsum U., Malmnäs Tjernlund U. K., Kabelitz D., Wigren A. Appearance of anti-HLA-DR-reactive cells in normal and rheumatoid synovial tissue. Scand J Immunol. 1981 Aug;14(2):183–192. doi: 10.1111/j.1365-3083.1981.tb00198.x. [DOI] [PubMed] [Google Scholar]
  10. Klareskog L., Forsum U., Wigren A., Wigzell H. Relationship between HLA-DR-expressing cells and T lymphocytes of different subsets in rheumatoid synovial tissue. Scand J Immunol. 1981 May;15(5):501–507. doi: 10.1111/j.1365-3083.1982.tb00676.x. [DOI] [PubMed] [Google Scholar]
  11. Kurosaka M., Ziff M. Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med. 1983 Oct 1;158(4):1191–1210. doi: 10.1084/jem.158.4.1191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Masi A. T., Maldonado-Cocco J. A., Kaplan S. B., Feigenbaum S. L., Chandler R. W. Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum. 1976 May;4(4):299–326. doi: 10.1016/0049-0172(76)90013-5. [DOI] [PubMed] [Google Scholar]
  13. Muirden K. D., Mills K. W. Do lymphocytes protect the rheumatoid joint? Br Med J. 1971 Oct 23;4(5781):219–221. doi: 10.1136/bmj.4.5781.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  15. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  16. Rooney M., Condell D., Quinlan W., Daly L., Whelan A., Feighery C., Bresnihan B. Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum. 1988 Aug;31(8):956–963. doi: 10.1002/art.1780310803. [DOI] [PubMed] [Google Scholar]
  17. Rooney M., Whelan A., Feighery C., Bresnihan B. Changes in lymphocyte infiltration of the synovial membrane and the clinical course of rheumatoid arthritis. Arthritis Rheum. 1989 Apr;32(4):361–369. doi: 10.1002/anr.1780320402. [DOI] [PubMed] [Google Scholar]
  18. Rooney M., Whelan A., Feighery C., Bresnihan B. The immunohistologic features of synovitis, disease activity and in vitro IgM rheumatoid factor synthesis by blood mononuclear cells in rheumatoid arthritis. J Rheumatol. 1989 Apr;16(4):459–467. [PubMed] [Google Scholar]
  19. Soden M., Whelan A., Feighery C., Bresnihan B. Lymphocyte infiltration and the synthesis of IgM and IgA rheumatoid factors by rheumatoid synovial membrane. Rheumatol Int. 1990;10(4):149–152. doi: 10.1007/BF02274839. [DOI] [PubMed] [Google Scholar]
  20. Waxman B. A., Sledge C. B. Correlation of histochemical, histologic and biochemical evaluations of human synovium with clinical activity. Arthritis Rheum. 1973 May-Jun;16(3):376–382. doi: 10.1002/art.1780160313. [DOI] [PubMed] [Google Scholar]
  21. Yates D. B., Scott J. T. Rheumatoid synovitis and joint disease. Relationship between arthroscopic and histological changes. Ann Rheum Dis. 1975 Feb;34(1):1–6. doi: 10.1136/ard.34.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]

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