Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1991 Oct;50(10):691–693. doi: 10.1136/ard.50.10.691

T cell receptor expression in Sjögren's syndrome.

A Zumla 1, M Mathur 1, J Stewart 1, L Wilkinson 1, D Isenberg 1
PMCID: PMC1004532  PMID: 1720300

Abstract

T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren's syndrome. The cellular infiltrates for the surface phenotypic markers for alpha/beta and gamma/delta T cell receptors, CD4, CD8, CD45, and CD5 were examined in lip biopsy specimens from two patients with primary Sjögren's syndrome, six with secondary Sjögren's syndrome, and seven healthy controls. Most of the Sjögren's lip biopsy cellular infiltrates were T lymphocytes of the CD4 subset expressing the alpha/beta T cell receptor (mean 70%). The low prevalence of gamma/delta T cell receptor bearing cells in lip biopsy specimens is maintained in Sjögren's syndrome (mean 1.5%), and thus it seems unlikely that these lymphocytes bearing the gamma/delta T cell receptor have a major role in the immunopathology of Sjögren's syndrome. Over 70% of cells within the lesional infiltrate of primary and secondary Sjögren's syndrome expressed the CD5 and CD45 cell surface molecules.

Full text

PDF
692

Images in this article

692Image
on p.692
692Image
on p.692

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brennan F. M., Londei M., Jackson A. M., Hercend T., Brenner M. B., Maini R. N., Feldmann M. T cells expressing gamma delta chain receptors in rheumatoid arthritis. J Autoimmun. 1988 Aug;1(4):319–326. doi: 10.1016/0896-8411(88)90002-9. [DOI] [PubMed] [Google Scholar]
  2. Brennan F., Plater-Zyberk C., Maini R. N., Feldmann M. Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome. Clin Exp Immunol. 1989 Aug;77(2):175–178. [PMC free article] [PubMed] [Google Scholar]
  3. Dauphinée M., Tovar Z., Talal N. B cells expressing CD5 are increased in Sjögren's syndrome. Arthritis Rheum. 1988 May;31(5):642–647. doi: 10.1002/art.1780310509. [DOI] [PubMed] [Google Scholar]
  4. Firestein G. S., Zvaifler N. J. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 1990 Jun;33(6):768–773. doi: 10.1002/art.1780330602. [DOI] [PubMed] [Google Scholar]
  5. Fox R. I., Carstens S. A., Fong S., Robinson C. A., Howell F., Vaughan J. H. Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjögren's syndrome. Arthritis Rheum. 1982 Apr;25(4):419–426. doi: 10.1002/art.1780250410. [DOI] [PubMed] [Google Scholar]
  6. Hsu S. M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. doi: 10.1177/29.4.6166661. [DOI] [PubMed] [Google Scholar]
  7. Moutsopoulos H. M., Manoussakis M. N. Immunopathogenesis of Sjogren's syndrome: "facts and fancy". Autoimmunity. 1989;5(1-2):17–24. doi: 10.3109/08916938909029139. [DOI] [PubMed] [Google Scholar]
  8. Pardoll D. M., Kruisbeek A. M., Fowlkes B. J., Coligan J. E., Schwartz R. H. The unfolding story of T cell receptor gamma. FASEB J. 1987 Aug;1(2):103–109. doi: 10.1096/fasebj.1.2.2956146. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES