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. 1992 Jan;51(1):56–60. doi: 10.1136/ard.51.1.56

Peripheral vascular disease in patients with systemic lupus erythematosus.

J McDonald 1, J Stewart 1, M B Urowitz 1, D D Gladman 1
PMCID: PMC1004619  PMID: 1540039

Abstract

Patients with systemic lupus erythematosus may develop premature atherosclerosis, notably coronary artery disease. A group of 10 patients with peripheral vascular disease presenting with intermittent claudication or gangrene were studied from a group of 563 patients followed prospectively at the Wellesley Hospital Lupus Clinic. These 10 patients were compared with the next lupus clinic patient matched for age and sex, with respect to demographic characteristics and risk factors. The patients and controls did not differ significantly in lupus activity criteria count, partial thromboplastin time, the number with antibody to cardiolipin, number receiving steroids or mean steroid dose, family history of atherosclerosis, hyperlipidaemia, smoking, hypertension or use of oral contraceptives. The risk factors for developing peripheral vascular disease were a longer duration of systemic lupus erythematosus and a longer duration of use of steroids. Eight of the 10 patients had coexistent coronary artery disease or transient ischaemic attack.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn S. S., Kalunian K., Rosove M., Moore W. S. Postoperative thrombotic complications in patients with lupus anticoagulant: increased risk after vascular procedures. J Vasc Surg. 1988 Jun;7(6):749–756. doi: 10.1067/mva.1988.avs0070749. [DOI] [PubMed] [Google Scholar]
  2. Ansari A., Larson P. H., Bates H. D. Vascular manifestations of systemic lupus erythematosus. Angiology. 1986 Jun;37(6):423–432. doi: 10.1177/000331978603700601. [DOI] [PubMed] [Google Scholar]
  3. Asherson R. A., Khamashta M. A., Gil A., Vazquez J. J., Chan O., Baguley E., Hughes G. R. Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am J Med. 1989 Apr;86(4):391–399. doi: 10.1016/0002-9343(89)90335-5. [DOI] [PubMed] [Google Scholar]
  4. Asherson R. A., Merry P., Acheson J. F., Harris E. N., Hughes G. R. Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the 'primary' antiphospholipid syndrome. Ann Rheum Dis. 1989 May;48(5):358–361. doi: 10.1136/ard.48.5.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bulkley B. H., Roberts W. C. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients. Am J Med. 1975 Feb;58(2):243–264. doi: 10.1016/0002-9343(75)90575-6. [DOI] [PubMed] [Google Scholar]
  6. DePalma R. G., Moskowitz R. W., Holden W. D. Peripheral ischemia and collagen disease: clinical manifestations, diagnosis, and treatment. Arch Surg. 1972 Aug;105(2):313–318. doi: 10.1001/archsurg.1972.04180080161027. [DOI] [PubMed] [Google Scholar]
  7. Gladman D. D., Urowitz M. B. Morbidity in systemic lupus erythematosus. J Rheumatol Suppl. 1987 Jun;14 (Suppl 13):223–226. [PubMed] [Google Scholar]
  8. Gladstein G. S., Rynes R. I., Parhami N., Bartholomew L. E. Gangrene of a foot secondary to systemic lupus erythematosus with large vessel vasculitis. J Rheumatol. 1979 Sep-Oct;6(5):549–553. [PubMed] [Google Scholar]
  9. Harris E. N., Gharavi A. E., Asherson R. A., Boey M. L., Hughes G. R. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol. 1984 Jan-Mar;2(1):47–51. [PubMed] [Google Scholar]
  10. Harris E. N., Gharavi A. E., Patel S. P., Hughes G. R. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol. 1987 Apr;68(1):215–222. [PMC free article] [PubMed] [Google Scholar]
  11. KEAT E. C., SHORE J. H. Gangrene of the legs in disseminated lupus erythematosus. Br Med J. 1958 Jan 4;1(5061):25–27. doi: 10.1136/bmj.1.5061.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meller J., Conde C. A., Deppisch L. M., Donoso E., Dack S. Myocardial infarction due to coronary atherosclerosis in three young adults with systemic lupus erythematosus. Am J Cardiol. 1975 Feb;35(2):309–314. doi: 10.1016/0002-9149(75)90019-3. [DOI] [PubMed] [Google Scholar]
  13. Ross R. The pathogenesis of atherosclerosis--an update. N Engl J Med. 1986 Feb 20;314(8):488–500. doi: 10.1056/NEJM198602203140806. [DOI] [PubMed] [Google Scholar]
  14. Rubin L. A., Urowitz M. B., Gladman D. D. Mortality in systemic lupus erythematosus: the bimodal pattern revisited. Q J Med. 1985 Apr;55(216):87–98. [PubMed] [Google Scholar]
  15. Spiera H., Rothenberg R. R. Myocardial infarction in four young patients with SLE. J Rheumatol. 1983 Jun;10(3):464–466. [PubMed] [Google Scholar]
  16. Spiera H., Rothenberg R. R. Myocardial infarction in four young patients with SLE. J Rheumatol. 1983 Jun;10(3):464–466. [PubMed] [Google Scholar]
  17. Tsakraklides V. G., Blieden L. C., Edwards J. E. Coronary atherosclerosis and myocardial infarction associated with systemic lupus erythematosus. Am Heart J. 1974 May;87(5):637–641. doi: 10.1016/0002-8703(74)90504-3. [DOI] [PubMed] [Google Scholar]
  18. Urowitz M. B., Bookman A. A., Koehler B. E., Gordon D. A., Smythe H. A., Ogryzlo M. A. The bimodal mortality pattern of systemic lupus erythematosus. Am J Med. 1976 Feb;60(2):221–225. doi: 10.1016/0002-9343(76)90431-9. [DOI] [PubMed] [Google Scholar]
  19. Urowitz M. B., Gladman D. D., Tozman E. C., Goldsmith C. H. The lupus activity criteria count (LACC). J Rheumatol. 1984 Dec;11(6):783–787. [PubMed] [Google Scholar]

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