Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Jun;51(6):769–776. doi: 10.1136/ard.51.6.769

Primary Sjögren's syndrome with antibodies to HTLV-I: clinical and laboratory features.

K Eguchi 1, N Matsuoka 1, H Ida 1, M Nakashima 1, M Sakai 1, S Sakito 1, A Kawakami 1, K Terada 1, H Shimada 1, Y Kawabe 1, et al.
PMCID: PMC1004744  PMID: 1352097

Abstract

The prevalence of antibodies to human T lymphotropic virus type I (HTLV-I) was studied in patients with primary Sjögren's syndrome. Thirteen of 36 serum samples were positive by enzyme linked immunosorbent assay (ELISA) and particle agglutination assay for antibodies to HTLV-I and were confirmed by western blotting. The presence of antibodies to HTLV-I may signify an HTLV-I carrier state. These patients had a high occurrence of extraglandular manifestations such as uveitis, myopathy, and recurrent high fever compared with patients who did not have antibodies to HTLV-I. Patients with antibodies to HTLV-I had an increased spontaneous proliferation of peripheral blood mononuclear cells compared with those without the antibodies. The proportions of activated and memory T cells (HLA-DR+ CD3+, CD25+ CD3+, and CD29+ CD4+ cells) were higher in HTLV-I carriers than in non-carriers. The presence of antibodies to HTLV-I in some patients with primary Sjögren's syndrome suggests that HTLV-I may cause primary Sjögren's syndrome or its extraglandular manifestations, or both.

Full text

PDF
776

Images in this article

771Image
on p.771
773Image
on p.773

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bhagavati S., Ehrlich G., Kula R. W., Kwok S., Sninsky J., Udani V., Poiesz B. J. Detection of human T-cell lymphoma/leukemia virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy. N Engl J Med. 1988 May 5;318(18):1141–1147. doi: 10.1056/NEJM198805053181801. [DOI] [PubMed] [Google Scholar]
  2. Calabrese L. H., Wilke W. S., Perkins A. D., Tubbs R. R. Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome. Arthritis Rheum. 1989 Nov;32(11):1453–1457. doi: 10.1002/anr.1780321115. [DOI] [PubMed] [Google Scholar]
  3. Couderc L. J., Caubarrere I., Venet A., Magdeleine J., Jouanelle A., Danon F., Buisson G., Vernant J. C. Bronchoalveolar lymphocytosis in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type 1 (HTLV-1). Clinical, immunologic, and cytologic studies. Ann Intern Med. 1988 Oct 15;109(8):625–628. doi: 10.7326/0003-4819-109-8-625. [DOI] [PubMed] [Google Scholar]
  4. Desgranges C., Bechet J. M., Couderc L. J., Caubarrere I., Vernant J. C. Detection of HTLV-1 DNA by polymerase chain reaction in alveolar lymphocytes of patients with tropical spastic paraparesis. J Infect Dis. 1989 Jul;160(1):162–163. doi: 10.1093/infdis/160.1.162. [DOI] [PubMed] [Google Scholar]
  5. Eguchi K., Aoyagi T., Nakashima M., Migita K., Kawakami A., Tsukasaki K., Mine M., Maeda K., Nagataki S. A case of adult T cell leukemia complicated by proliferative synovitis. J Rheumatol. 1991 Feb;18(2):297–299. [PubMed] [Google Scholar]
  6. Eguchi K., Otsubo T., Kawabe Y., Ueki Y., Fukuda T., Matsunaga M., Shimomura C., Ishikawa N., Tezuka H., Nakao H. The remarkable proliferation of helper T cell subset in response to autologous thyrocytes and intrathyroidal T cells from patients with Graves' disease. Clin Exp Immunol. 1987 Nov;70(2):403–410. [PMC free article] [PubMed] [Google Scholar]
  7. Eguchi K., Ueki Y., Shimomura C., Otsubo T., Nakao H., Migita K., Kawakami A., Matsunaga M., Tezuka H., Ishikawa N. Increment in the Ta1+ cells in the peripheral blood and thyroid tissue of patients with Graves' disease. J Immunol. 1989 Jun 15;142(12):4233–4240. [PubMed] [Google Scholar]
  8. Garry R. F., Fermin C. D., Hart D. J., Alexander S. S., Donehower L. A., Luo-Zhang H. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV. Science. 1990 Nov 23;250(4984):1127–1129. doi: 10.1126/science.1701273. [DOI] [PubMed] [Google Scholar]
  9. Gazzolo L., Duc Dodon M. Direct activation of resting T lymphocytes by human T-lymphotropic virus type I. Nature. 1987 Apr 16;326(6114):714–717. doi: 10.1038/326714a0. [DOI] [PubMed] [Google Scholar]
  10. Gessain A., Barin F., Vernant J. C., Gout O., Maurs L., Calender A., de Thé G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985 Aug 24;2(8452):407–410. doi: 10.1016/s0140-6736(85)92734-5. [DOI] [PubMed] [Google Scholar]
  11. Gordon J. J., Golbus J., Kurtides E. S. Chronic lymphadenopathy and Sjogren's syndrome in a homosexual man. N Engl J Med. 1984 Nov 29;311(22):1441–1442. doi: 10.1056/NEJM198411293112214. [DOI] [PubMed] [Google Scholar]
  12. Green J. E., Hinrichs S. H., Vogel J., Jay G. Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature. 1989 Sep 7;341(6237):72–74. doi: 10.1038/341072a0. [DOI] [PubMed] [Google Scholar]
  13. Hinuma Y., Nagata K., Hanaoka M., Nakai M., Matsumoto T., Kinoshita K. I., Shirakawa S., Miyoshi I. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476–6480. doi: 10.1073/pnas.78.10.6476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hospice comes of age. Lancet. 1986 May 3;1(8488):1013–1014. [PubMed] [Google Scholar]
  15. Ichikawa Y., Shimizu H., Yoshida M., Arimori S. Activation antigens expressed on T-cells of the peripheral blood in Sjögren's syndrome and rheumatoid arthritis. Clin Exp Rheumatol. 1990 May-Jun;8(3):243–249. [PubMed] [Google Scholar]
  16. Ichikawa Y., Shimizu H., Yoshida M., Arimori S. Activation of T cell subsets in the peripheral blood of patients with Sjögren's syndrome. Multicolor flow cytometric analysis. Arthritis Rheum. 1990 Nov;33(11):1674–1681. doi: 10.1002/art.1780331110. [DOI] [PubMed] [Google Scholar]
  17. Ishikawa N., Eguchi K., Otsubo T., Ueki Y., Fukuda T., Tezuka H., Matsunaga M., Kawabe Y., Shimomura C., Izumi M. Reduction in the suppressor-inducer T cell subset and increase in the helper T cell subset in thyroid tissue from patients with Graves' disease. J Clin Endocrinol Metab. 1987 Jul;65(1):17–23. doi: 10.1210/jcem-65-1-17. [DOI] [PubMed] [Google Scholar]
  18. Itoyama Y., Minato S., Goto I., Okochi K., Yamamoto N. Elevated serum antibody titers to Epstein-Barr virus in HTLV-I-associated myelopathy (HAM). Neurology. 1988 Oct;38(10):1650–1653. doi: 10.1212/wnl.38.10.1650. [DOI] [PubMed] [Google Scholar]
  19. Itoyama Y., Minato S., Kira J., Goto I., Sato H., Okochi K., Yamamoto N. Altered subsets of peripheral blood lymphocytes in patients with HTLV-I associated myelopathy (HAM). Neurology. 1988 May;38(5):816–818. doi: 10.1212/wnl.38.5.816. [DOI] [PubMed] [Google Scholar]
  20. Itoyama Y., Minato S., Kira J., Goto I., Sato H., Okochi K., Yamamoto N. Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy. Neurology. 1988 Aug;38(8):1302–1307. doi: 10.1212/wnl.38.8.1302. [DOI] [PubMed] [Google Scholar]
  21. Katsuki T., Katsuki K., Imai J., Hinuma Y. Immune suppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-I): impairment of T-cell control of Epstein-Barr virus-infected B-cells. Jpn J Cancer Res. 1987 Jul;78(7):639–642. [PubMed] [Google Scholar]
  22. Leung K., Nabel G. J. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature. 1988 Jun 23;333(6175):776–778. doi: 10.1038/333776a0. [DOI] [PubMed] [Google Scholar]
  23. Matsumoto M., Sugimoto M., Nakashima H., Imamura F., Kawano O., Uyama E., Takatsu K., Araki S. Spontaneous T cell proliferation and release of soluble interleukin-2 receptors in patients with HTLV-I-associated myelopathy. Am J Trop Med Hyg. 1990 Apr;42(4):365–373. doi: 10.4269/ajtmh.1990.42.365. [DOI] [PubMed] [Google Scholar]
  24. Matutes E., Dalgleish A. G., Weiss R. A., Joseph A. P., Catovsky D. Studies in healthy human T-cell-leukemia lymphoma virus (HTLV-I) carriers from the Caribbean. Int J Cancer. 1986 Jul 15;38(1):41–45. doi: 10.1002/ijc.2910380108. [DOI] [PubMed] [Google Scholar]
  25. Miyoshi I., Kubonishi I., Yoshimoto S., Akagi T., Ohtsuki Y., Shiraishi Y., Nagata K., Hinuma Y. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature. 1981 Dec 24;294(5843):770–771. doi: 10.1038/294770a0. [DOI] [PubMed] [Google Scholar]
  26. Mori M., Kinoshita K., Ban N., Yamada Y., Shiku H. Activated T-lymphocytes with polyclonal gammopathy in patients with human T-lymphotropic virus type I--associated myelopathy. Ann Neurol. 1988 Aug;24(2):280–282. doi: 10.1002/ana.410240220. [DOI] [PubMed] [Google Scholar]
  27. Ohba N., Matsumoto M., Sameshima M., Kabayama Y., Nakao K., Unoki K., Uehara F., Kawano K., Maruyama I., Osame M. Ocular manifestations in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol. 1989;33(1):1–12. [PubMed] [Google Scholar]
  28. Romain P. L., Schlossman S. F. Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures. J Clin Invest. 1984 Nov;74(5):1559–1565. doi: 10.1172/JCI111571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sugimoto M., Nakashima H., Watanabe S., Uyama E., Tanaka F., Ando M., Araki S., Kawasaki S. T-lymphocyte alveolitis in HTLV-I-associated myelopathy. Lancet. 1987 Nov 21;2(8569):1220–1220. doi: 10.1016/s0140-6736(87)91362-6. [DOI] [PubMed] [Google Scholar]
  30. Talal N., Dauphinée M. J., Dang H., Alexander S. S., Hart D. J., Garry R. F. Detection of serum antibodies to retroviral proteins in patients with primary Sjögren's syndrome (autoimmune exocrinopathy). Arthritis Rheum. 1990 Jun;33(6):774–781. doi: 10.1002/art.1780330603. [DOI] [PubMed] [Google Scholar]
  31. Ulirsch R. C., Jaffe E. S. Sjögren's syndrome-like illness associated with the acquired immunodeficiency syndrome-related complex. Hum Pathol. 1987 Oct;18(10):1063–1068. doi: 10.1016/s0046-8177(87)80223-x. [DOI] [PubMed] [Google Scholar]
  32. Vernant J. C., Buisson G., Magdeleine J., De Thore J., Jouannelle A., Neisson-Vernant C., Monplaisir N. T-lymphocyte alveolitis, tropical spastic paresis, and Sjögren syndrome. Lancet. 1988 Jan 23;1(8578):177–177. doi: 10.1016/s0140-6736(88)92744-4. [DOI] [PubMed] [Google Scholar]
  33. Wiley C. A., Nerenberg M., Cros D., Soto-Aguilar M. C. HTLV-I polymyositis in a patient also infected with the human immunodeficiency virus. N Engl J Med. 1989 Apr 13;320(15):992–995. doi: 10.1056/NEJM198904133201507. [DOI] [PubMed] [Google Scholar]
  34. Yamaguchi K., Nishimura Y., Kiyokawa T., Takatsuki K. Elevated serum levels of soluble interleukin-2 receptors in HTLV-I--associated myelopathy. J Lab Clin Med. 1989 Oct;114(4):407–410. [PubMed] [Google Scholar]
  35. Yoshida M., Osame M., Usuku K., Matsumoto M., Igata A. Viruses detected in HTLV-I-associated myelopathy and adult T-cell leukaemia are identical on DNA blotting. Lancet. 1987 May 9;1(8541):1085–1086. doi: 10.1016/s0140-6736(87)90506-x. [DOI] [PubMed] [Google Scholar]
  36. Yoshida M., Seiki M., Yamaguchi K., Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2534–2537. doi: 10.1073/pnas.81.8.2534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. de Clerck L. S., Couttenye M. M., de Broe M. E., Stevens W. J. Acquired immunodeficiency syndrome mimicking Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum. 1988 Feb;31(2):272–275. doi: 10.1002/art.1780310216. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES