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. 1992 Sep;51(9):1071–1073. doi: 10.1136/ard.51.9.1071

False positive results for antibody to HIV in two men with systemic lupus erythematosus.

M H Esteva 1, A M Blasini 1, D Ogly 1, M A Rodríguez 1
PMCID: PMC1004841  PMID: 1417140

Abstract

False positive results were obtained for HIV tests in two men with active systemic lupus erythematosus (SLE) who were suspected of being infected with HIV because of fever, weight loss, lymphadenopathy, and inflammatory myopathy. Enzyme linked immunosorbent assays (ELISAs) for HIV were twice positive when tested three times over a period of six months. Western blot analysis showed reactivity against the gp41 band in patient 1. False positive results for HIV tests can occur in patients with SLE, potentially leading to an erroneous diagnosis of HIV infection.

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Selected References

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  1. Buskila D., Gladman D. Musculoskeletal manifestations of infection with human immunodeficiency virus. Rev Infect Dis. 1990 Mar-Apr;12(2):223–235. doi: 10.1093/clinids/12.2.223. [DOI] [PubMed] [Google Scholar]
  2. Golding H., Robey F. A., Gates F. T., 3rd, Linder W., Beining P. R., Hoffman T., Golding B. Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp41-derived peptide and patients' sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immune deficiency syndrome. J Exp Med. 1988 Mar 1;167(3):914–923. doi: 10.1084/jem.167.3.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kalden J. R., Winkler T., Krapf F. Are retroviruses involved in the aetiology of rheumatic diseases? Br J Rheumatol. 1991;30 (Suppl 1):63–69. [PubMed] [Google Scholar]
  4. Leo-Amador G. E., Ramírez-Rodríguez J. M., Galván-Villegas F., Perla-Navarro A. V. Anticuerpos contra el virus de la immunodeficiencia humana en lupus eritematoso generalizado. Salud Publica Mex. 1990 Jan-Feb;32(1):15–19. [PubMed] [Google Scholar]
  5. Midthun K., Garrison L., Clements M. L., Farzadegan H., Fernie B., Quinn T. Frequency of indeterminate western blot tests in healthy adults at low risk for human immunodeficiency virus infection. The NIAID AIDS Vaccine Clinical Trails Network. J Infect Dis. 1990 Dec;162(6):1379–1382. doi: 10.1093/infdis/162.6.1379. [DOI] [PubMed] [Google Scholar]
  6. Okudaira K., Searles R. P., Ceuppens J. L., Goodwin J. S., Williams R. C., Jr Anti-Ia reactivity in sera from patients with systemic lupus erythematosus. J Clin Invest. 1982 Jan;69(1):17–24. doi: 10.1172/JCI110428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Olsen R. G., Tarr M. J., Mathes L. E., Whisler R., Du Plessis D., Schulz E. J., Blakeslee J. R. Serological and virological evidence of human T-lymphotropic virus in systemic lupus erythematosus. Med Microbiol Immunol. 1987;176(2):53–64. doi: 10.1007/BF00200675. [DOI] [PubMed] [Google Scholar]
  8. Pelton B. K., North M., Palmer R. G., Hylton W., Smith-Burchnell C., Sinclair A. L., Malkovsky M., Dalgleish A. G., Denman A. M. A search for retrovirus infection in systemic lupus erythematosus and rheumatoid arthritis. Ann Rheum Dis. 1988 Mar;47(3):206–209. doi: 10.1136/ard.47.3.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  10. Winchester R. AIDS and the rheumatic diseases. Bull Rheum Dis. 1990;39(5):1–10. [PubMed] [Google Scholar]

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